Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Secretin or gastrin; related peptides
Patent
1990-02-28
1993-03-16
Lacey, David L.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Secretin or gastrin; related peptides
530327, 530328, 530329, 424858, C07K 732, C07K 706, C07K 708, A61K 3702
Patent
active
051945851
ABSTRACT:
Specific, selective inhibitors of catalytic antibodies both synthetic and naturally occurring, their use and compositions thereof are disclosed. In particular, an inhibitor preventing the hydrolysis of the peptide bond between amino acid residues 16 and 17 in the neurotransmitter vasoactive intestinal peptide (VIP) by an anti-VIP catalytic autoantibody is disclosed.
REFERENCES:
patent: 4196265 (1980-04-01), Koprowski et al.
patent: 4376110 (1983-03-01), David et al.
patent: 4492751 (1985-01-01), Boguslaski et al.
patent: 4493890 (1985-01-01), Morris
patent: 4659567 (1987-04-01), Tramontano et al.
patent: 4661586 (1987-04-01), Levy et al.
patent: 4792446 (1988-12-01), Kim et al.
patent: 4888281 (1989-12-01), Schochetman
patent: 4900674 (1990-02-01), Benkovic
Lerner et al., "At the Crossroads of Chemistry and Immunology: Catalytic Antibodies", Science 252:659-667, 3 May 1991.
Paul et al., "Affinity Chromatography of Catalytic Autoantibody to Vasoactive Intestinal Peptide", J. Immunol. 145:1196-1199, Aug. 15, 1990.
Paul et al., "Autoantibody to Vasoactive Intestinal Peptide in Human Circulation," Biochim. Biophys. Res. Comm. 130:479-485, Jul. 16, 1985.
Paul et al., "Human Autoantibody to Vasoactive Intestinal Peptide: Increased Incidence in Muscular Exercise", Life Sciences 43:1079-1084, 1988.
Paul et al., "Characterization of Autoantibodies to Vasoactive Intestinal Peptide in Asthma," J. Neuroimmunol. 23:133-142, 1989.
Paul et al., "Catalytic Hydrolysis of Vasoactive Intestinal Peptide by Human Autoantibody," Science 244:1158-1162, 9 Jun. 1989.
Itoh et al., "Human Preprovasoactive Intestinal Polypeptide Contains a Novel PHI-27-like Peptide, PHM-27," Nature 304:547-549, 11 Aug. 1983.
Lerner, R. A., "Antibodies of Predetermined Specificity in Biology and Medicine," Adv. Immunol. 36:1-40, 1984.
Jerne et al., "Recurrent Idiotypes and Internal Images,"]EMBO Journal 1:243-247, 1982.
Berchtold et al., Blood vol. 74, No. 7, pp. 2414-2417 (1989).
Nobeyuki et al., Nature, vol. 304, pp. 547-549 (1983).
Edwards et al., "Human Monoclonal Antibodies and the Selection AF Antigens Suitable for Therapy" in Monoclonal Antibodies '84: Biological and Clinical Applications; Proceedings of the International Symposium on Monoclonal Antibodies '84 held in Florence, Italy, Oct. 16-19, 1984.
Pauling, L., Nature 161, 707, (1948).
Kohen, F., Kim, J. B., Lindner, H. R., Eshhar, Z., Green, B., "Antibody enhanced hydrolsis of steroid esters", Bioch. et Bioph. Acta 629, 328-337 (1980).
Pollack, S. J., Jacobs., J. W., Schultz, P. G., Science 234, 1570 (1986).
A. Tramontano, A. A. Amman, R. A. Lerner, J. Am. Chem. Soc. 110, 2282 (1988).
K. D. Janda, D. Schloeder, S. J. Benkovic, R. A. Lerner, Science 241: 1188 (1988).
C. N. Durfor, R. J. Bolin, R. J. Sugasawara, R. J. Massey, J. W. Jacobs, P. G. Schultz, J. Am. Chem. Soc. 110:8713 (1988).
Jackson, D. Y. et al., J. Am. Chem. Soc. 110, 4841 (1988); D. Hilvert, S. H. Carpenter, K. D. Nared, N. T. Auditor, Proc. Natl. Acad. Sci. USA 85: 4953 (1988).
Shokat, K. Leumann, Sugasawara, R. J., Schultz, P. G., Angew. Chem. Int. Engl. 27, 1172 (1988).
Bloom, S. R., Barnes, A. J. Adrian, T. E. Polak, J. M. "Autoimmunity in diabetics induced by hormonal contaminants of insulin", Lancet, 14-17, (1979).
Paul, S., Said, S. I., "Characterization of receptors for vasoactive intestinal peptide from the Lung", J. Biol. Chem. 262, 158-162 (1987).
Paul, S., Wood, K., Said, S. I. "Purification of [.sup.125 I]-Vasoactive intestinal peptide by reverse--phase HPLC", Peptides 5, 1085-1987 (1984).
Turner, J. T., Bylund, D. B., "Characterization of the VIP receptor in rat submandibular bland: Radiologand binding assay in membrane preparations", J. Pharmacol Exp. Therap. 242, 873-881 (1987).
Steinitz, M., Klein, G., Koskimies, S., Makela, O., "EB Virus induced B lymphocyte lines producing specific antibodies", Nature 269, 420-422 (1977).
Tramontano, A. et al., "Chemical Reactivity At An Antibody Binding Site Elicited By Mechanistic Design Of A Synthetic Antigen", P.N.A.S.(USA), 83, 6736-6740 (1986).
Pollack, S. J., and Schultz, P. G., "Antibody Catalysis by Transition State Stabilization", Cold Spring Harbor Symposium on Quantitative Biology, 52, 97-104 (1987).
Tramontano, A. et al., "Catalytic Antibodies", Science, 234, 1566-1570 (1986).
Cochran, A. G. et al., "Photosensitized Cleavage of a Thymine Dimer by an Antibody", J. Am. Chem. Soc. 110: 7888-7890 (1988).
Moe, K., "Scripps, UC Create `Killer` Antibodies", S. D. Union, Dec. 12, 1986.
Bulletin, Office of Public Information, Berkeley Campus, University of California, Dec. 9, 1986.
Marx, J. "Making Antibodies Work Like Enzymes", Science, 234, 1497-1498 (1986).
Jacobs, J. et al., "Catalytic Antibodies", J. Am. Chem. Soc., 109, 2174-2176 (1987).
"Antibody Catalyzes Stereospecific Reaction", Science/Technology Concentrates, C&EN, 15 Aug. 3, 1987.
Baum, R. M., "Catalytic Antibodies Open Up New Strategy For Protein Engineering", Science, C&EN, 30-33, Apr. 6, 1987.
Napper, A. "A Stereospecific Cyclization Catalyzed By An Antibody", Science, 237, 1041-1043 (1987).
Hansen, D. "Antibodies With Some Bite", Nature, 325, 304 (1987).
"Cancer Breakthrough Seen--IGEN Discovers New Protein Class", Rockville Gazette, Jan. 21, 1987.
Massey, R., "Catalytic Antibodies Catching On", Reprint from Nature, 328, No. 6129, 457-458 (1987).
Highfeld, R., "Aids Drug A Step Nearer", The Daily Telegraph, 9, Aug. 4, 1987.
"Abzymes", Scientific American, 256, No. 2, 84-85 (1987).
Steinitz, M., Seppala, I., Eichmann, K., Klein, G., "Establishment of a Human Lymphoblastoid Cell Line with Specific antibody production against group A streptococcal carbohydrate", Immunobiology 156, 41-47 (1979).
Steinitz, M., Izak, G., Cohen, S., Ehrenfeld, M., Flechner, I., "Continuous production of monoclonal rheumatoid Factor by EBV-transformed lymphocytes", Nature 287, 443-445, (1980).
Kozbor, D., Steinitz, M., Klein, G., Koskimies, S., Maketa, O., "Establishment of anti-TNP antibody-producing human lymphoid lines by preselection for hapten binding followed by EBV transformation", Scand. J. Immunol. 10, 187-194 (1979).
Kozbor, D. & Roder, J., The production of monoclonal antibodies from human lymphocytes. Immunology Today 4, 72-79 (1983).
Roder, J., Cole, D., Kozbor, D., "The EBV-Hybridoma Technique", Methods in Enzymology 121, 140-167 (1986).
Kohler, G., Milstein C., "Continuous Cultures of Fused Cells Secreting Antibody of Predefined Specificity", Nature 256, 445-497 (1975).
W. P. Jencks, "Catalysis In Chemistry And Enzymology", 288 (McGraw Hill, New York 1969).
Slobin, L., "Preparation And Some Properties of Antibodies With Specificity Towards p-Nitrophenylesters", Biochemistry, 5, 2836-2844 (1966).
Raso, V. and Stollar, B. D., "The Antibody-Enzyme Analogy. Characterization Of Antibodies To Phosphopyriodo-xyltyrosine Derivatives", Biochemistry, 14, 584-591 (1975).
Raso, V., and Stollar, B. D., "Antibodies Specific For Conformationally Distinct Coenzyme Substrate Transition State Analogs . . . ", J. Am. Chem. Soc., 95(5), 1621-1628 (1973).
Raso, V., and Stollar, B. D., "The Antibody-Enzyme Analogy, Comparison Of Enzymes And Antibodies Specific For Phosphopyriodoxyltyrosine", Biochemistry, 14, 591-599 (1975).
Burd, J. et al., "Specific Protein-Binding Reactions Monitored By Enzymatic Hydrolysis Of Ligands-Fluorescent Dye Conjugates", Analytical Biochemistry, 77, 56-67 (1977).
Kohen, F. et al., "A Steroid Immunoassay Based On Antibody-Enhanced Hydrolysis Of A Steroid-Umbelliferone Conjugate", FEBS Letters, 100, 137-140 (1979).
Kohen, F. et al., "Nonradioisotopic Homogeneous Steroid Immunoassays", J. Steroid Biochemistry, 11, 161-167 (1979).
Kohen, F. et al., "Monoclonal Immunoglobulin G Augments Hydrolysis Of An Ester Of The Homologous Hapten", FEBS Letters, 111, 427-431 (1980).
Kohen et al., FEBS Letters, 104, 201-205 (1979).
Royer, G. P., "Enzyme-Like Synthetic Catalysts (Synzymes)", Advances In Catalysis, 29, 197-227 (1980).
Summers, J. B., Jr., "Catalytic Principles Of Enzyme Chemistry: Antibody Models And Stereo Electronic Control", Harvard University Ph.D. Thesis, 22-101 (1983).
Fra
Massey Richard J.
Paul Sudhir
Powell Michael J.
Budens Robert D.
Evans Barry
IGEN, Inc.
Lacey David L.
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