Inhibitors of bruton's tyrosine kinase

Details Inhibitors of bruton's tyrosine kinase Inhibitors of bruton's tyrosine kinase

2011-03-08

2011-03-08

Anderson, Rebecca L (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C544S237000

Reexamination Certificate

active

07902194

ABSTRACT:
This application discloses 5-phenyl-1H-pyridin-2-one and 6-phenyl-2H-pyridazin-3-one derivatives according to generic Formulae I-IV:wherein, variables R, X, Y1, Y2, Y2, Y3, Y4, n and m are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions comprising compounds of Formulae I-IV and at least one carrier, diluent or excipient.

REFERENCES:
patent: 2008/0153834 (2008-06-01), Blomgren et al.
patent: WO 2004/022562 (2004-03-01), None
patent: WO 2005/014599 (2005-02-01), None
patent: 2006099075 (2006-09-01), None
patent: 2006124731 (2006-11-01), None
patent: 2007021795 (2007-02-01), None
patent: 2007027528 (2007-03-01), None
patent: 2007027594 (2007-03-01), None
patent: 2007027729 (2007-03-01), None
patent: 2007136465 (2007-11-01), None
patent: 2008033854 (2008-03-01), None
patent: 2008033857 (2008-03-01), None
patent: 2008033858 (2008-03-01), None
patent: WO 2008/033854 (2008-03-01), None
patent: 2009039397 (2009-03-01), None
patent: 2009053269 (2009-04-01), None
patent: WO 2009/077334 (2009-06-01), None
Hunter, T.Cell(1987) 50:823-829.
Rastetter, et al.Annu Rev Med(2004) 55:477-503.
Khan et al.Immunity(1995) 3:283-299.
Ellmeier, et al.J. Exp. Med. (2000) 192:1611-1623.
Rosen, et al.New Eng. J. Med. (1995) 333:431.
Lindvall, et al.Immunol. Rev. (2005) 203:200-215.
Jansson and HolmdahlClin. Exp. Immunol. (1993) 94:459-465.
Pan, Z. et al.Chem. Med Chem. (2007) 2:58-61.
Iwaki, et al.J. Biol. Chem. (2005) 280:40261-40270.
Horwood, et al.J. Exp. Med. (2003) 197:1603-1611.
Islam and Smith,Immunol. Rev. (2000) 178:49-63.
Feldhahn, et al.J. Exp. Med. (2005) 201:1837-1852.
Vassilev, et al.J. Biol. Chem. (1998) 274, 1646-1656.

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