Inhibitors of .beta.-lactamases and uses therefor

Details Inhibitors of .beta.-lactamases and uses therefor Inhibitors of .beta.-lactamases and uses therefor

1998-06-12

2000-06-13

Weddington, Kevin E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Boron containing doai

514330, 514340, 514451, 514456, 514481, 514543, A61K 3169, A61K 31445, A61K 3144, A61K 3135, A61K 3127

Patent

active

060750146

ABSTRACT:
The invention provides novel non-.beta.-lactam inhibitors of .beta.-lactamases. In particular, the invention provides such inhibitors which are boronic acids of formula (1) which is set forth in the specification. These compounds may be used with .beta.-lactam antibiotics to treat .beta.-lactam-antibiotic-resistant bacterial infections. These compounds are also antibacterial by themselves. Finally, the invention provides a pharmaceutical composition comprising these compounds.

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