Inhibitors of .beta.-glucuronidase and their use in the treatmen

Details Inhibitors of .beta.-glucuronidase and their use in the treatmen Inhibitors of .beta.-glucuronidase and their use in the treatmen

1997-08-01

1998-10-06

Knode, Marian C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

514 24, 514 25, 514 42, 536 41, 536 172, 536 179, 536 182, 536 221, 536 291, 536 53, 536 54, 536 55, C07H 504, C07H 100, A61K 3170

Patent

active

058178007

ABSTRACT:
Compounds of the formulae I and II ##STR1## are suitable for the suppression of tumor growth and of tumor metastasis.

REFERENCES:
patent: 3903289 (1975-09-01), Magee
patent: 4990500 (1991-02-01), Vertesy et al.
patent: 5231185 (1993-07-01), Ganem et al.
patent: 5412082 (1995-05-01), Wittman et al.
Roland Hoos et al., "148. Synthesis and Enzymatic Evaluation of Substrates and Inhibitors of .beta.-Glucuronidases," Helvetica Chimica Acta, vol. 79, pp. 1757-1783 (1996).
Y. Naparstek et al., "Activated T Lymphocytes Produce a Matrix-Degrading Heparan Sulphate Endoglycosidade", Nature, 310:241-244 (1984).
T. Niwa et al., "a New Potent .beta.-Glucuronidase Inhibitor, D-Glucaro-.delta.-lactam Derived from Nojirimycin", J. Biochem, 72(1):207-211 (1972).
Nakajima et al., "Heparanases and Tumor Metastasis", J. of Cellular Biochemistry, 36:157-167 (1988).

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