Inhibitors of BCL-2

Details Inhibitors of BCL-2 Inhibitors of BCL-2

2008-08-13

2011-10-11

Russel, Jeffrey E (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S019200, C514S019300, C514S021300, C514S021400, C514S021500, C514S021600, C530S324000, C530S326000

Reexamination Certificate

active

08034779

ABSTRACT:
A purified polypeptide includes an amino acid sequence consisting of about 10 to 80 amino acids, the amino acid sequence having a sequence identity at least 90% homologous to a portion of SEQ ID NO:1. The polypeptide inhibits binding of Bcl-2 to IP3receptors of cells that express IP3R and Bcl-2 and induces apoptosis in a cell.

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patent: 2007/0072860 (2007-03-01), Bruncko et al.
Rong et al. Targeting Bcl-2-IP3 Receptor Interaction to Reverse BcI-2's Inhibition of Apoptotic Calcium Signals. Molecular Cell. Jul. 25, 2008. vol. 31, pp. 255-265.
Rong et al., “Targeting Bcl-2-IP3 Receptor Interaction to Reverse Bcl-2's Inhibition of Apoptotic Calcium Signals”, Molecular Cell, vol. 31, pp. 1-13.
Reed et al., “Apoptosis-based Therapies for Hematologic malignancies”, Blood, 15 Jul. 2005, vol. 106, No. 2, pg. 407-418.

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