Inhibitors of bacterial ribonucleotide reductase

Details Inhibitors of bacterial ribonucleotide reductase Inhibitors of bacterial ribonucleotide reductase

1992-06-18

1993-03-30

Cashion, Jr, Merrell C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 15, 530326, 530327, 530328, A61K 3700, A61K 3702, C07K 500, C07K 700

Patent

active

051984253

ABSTRACT:
Disclosed herein are peptides of the formula

REFERENCES:
patent: 4814432 (1989-03-01), Freidinger et al.
B. van't Riet, "Synthesis of Hydroxy-and Amino-Substituted Benzohydroxamic Acids: Inhibition of Ribonucleotide Reductase and Antitumor Activity", J. Med. Chem. 22(5): 589-592 (1979).
Gaudreau et al., "Structure-Activity Studies on Synthetic Peptides Inhibiting Herpes Simplex Virus Ribonucleotide Reductase", J. Biol. Chem. 262(26): 12413-12416 (1987).
Spector et al., "2-Acetylpyridine 5-[(dimethylamino)thiocarbonyl]-thiocarbonohydrazone (A1110U), a Potent Inactivator of Ribonucleotide Reductases of Herpes Simplex and Varicella-Zoster Viruses and a Potentiator of Acyclovir", Proc., Natl. Acad. Sci. USA 86: 1051-1055 (1989).

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