Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2003-07-02
2008-10-28
Aulakh, Charanjit S. (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C549S438000, C558S390000, C560S013000, C560S017000, C560S019000, C560S147000, C560S155000, C514S464000, C514S523000, C514S529000
Reexamination Certificate
active
07442718
ABSTRACT:
The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and consequently, may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. This invention also relates to methods for inhibiting the activity of HIV aspartyl protease using the compounds of this invention and methods for screening compounds for anti-HIV activity.
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Andrews, III Clarence W
Baker Christopher T
Furfine Eric S
Hale Michael R
Maltais Francois
Aulakh Charanjit S.
Haley, Jr James F.
Ropes & Gray LLP
Shin Tae Bum
Vertex Pharmaceuticals Incorporated
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