Inhibitors of AKT (protein kinase B)

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C546S139000

Reexamination Certificate

active

07998977

ABSTRACT:
4-[5-(2-Amino-ethanesulfonyl)-isoquinolin-7-yl]-phenol or a pharmaceutically acceptable salt thereof or a hydrate of the compound or the salt thereof as Akt inhibitors that are antineoplastic and/or antiviral agents as well as compositions comprising these compounds and methods of using these compounds.

REFERENCES:
patent: WO01/91754 (2001-12-01), None
patent: WO2004/094386 (2004-11-01), None
patent: WO2005/011697 (2005-02-01), None
patent: WO2005/054202 (2005-06-01), None
patent: WO 2005054202 (2005-06-01), None
Reuveni, H., “Toward a PKB Inhibitor: Modification of a Selective PKA Inhibitor by Rational Design,” Biochemistry, 2002, 41, pp. 10304-10314.

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