Inhibitors of Akt activity

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C544S344000, C544S345000, C544S277000

Reexamination Certificate

active

10510066

ABSTRACT:
The present invention is directed to compounds comprising a ring-fused quinoxalinyl moiety which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention

REFERENCES:
patent: 6329375 (2001-12-01), Tang et al.
patent: 2002/0127214 (2002-09-01), Hemmings
patent: 97/22360 (1997-06-01), None
patent: WO 99/07701 (1999-02-01), None
patent: 99/42461 (1999-06-01), None
patent: 01/34607 (2001-05-01), None
patent: 01/91754 (2001-12-01), None
patent: WO 02/094796 (2002-11-01), None
patent: WO 03/084473 (2003-10-01), None
Nakatani et al. J.Biol.Chem. vol. 274, p. 21528-21532 (1999).
Bellacosa et al. Intl.J.Cancer, vol. 64, p. 280-285 (1995).
Hanada et al. Biochimica et Biophysica Acta, vol. 1697, p. 3-16 (2004).

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