Inhibitors of Akt activity

Details Inhibitors of Akt activity Inhibitors of Akt activity

2007-12-04

2009-08-18

Berch, Mark L (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S256000, C514S293000, C544S333000, C544S281000, C544S126000, C544S405000, C544S238000, C544S350000, C544S346000, C544S127000, C544S279000, C546S122000, C560S027000

Reexamination Certificate

active

07576209

ABSTRACT:
The instant invention provides for substituted naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.

REFERENCES:
patent: 7034026 (2006-04-01), Barnett et al.
patent: 2003/0199511 (2003-10-01), Li et al.
patent: 2005/0130977 (2005-06-01), Lindsley et al.
patent: 2005/0159422 (2005-07-01), Lindsley et al.
patent: 2005/0182256 (2005-08-01), Duggan et al.
patent: 2005/0222155 (2005-10-01), Bilodeau et al.
patent: 2005/0288294 (2005-12-01), Duggan et al.
patent: 2006/0270673 (2006-11-01), Duggan et al.
patent: 2007/0043001 (2007-02-01), Bilodeau et al.
patent: 2007/0082906 (2007-04-01), Bilodeau et al.
patent: 2007/0254901 (2007-11-01), Bilodeau et al.
patent: 2008/0009507 (2008-01-01), Cosford et al.
patent: 2008/0015212 (2008-01-01), Barnett et al.
patent: 2008/0280889 (2008-11-01), Bilodeau et al.
patent: 1 679 308 (2006-07-01), None
patent: WO 2004/096130 (2004-11-01), None
patent: WO 2005/007099 (2005-01-01), None
patent: WO 2005/100356 (2005-10-01), None
patent: WO 2006/036395 (2006-04-01), None
patent: WO 2006/065601 (2006-06-01), None
patent: WO 2006/110638 (2006-10-01), None
patent: WO 2006/135627 (2006-12-01), None
Basso, et al., Oncogene (2002) 21, 1159-1166.
Frogne, et al., Endocrine-Related Cancer (2005) 12, 599-614.
Koul, et al., Mol. Cancer Ther. 2006;5:637-644.
Beresford, et al., J. Interferon & Cytokine Res. 21:313-322 (2001).
Altomare, et al., Oncogene (2004) 23, 5853-5857.

Affiliated with

Also associated with

Rating

Inhibitors of Akt activity does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Inhibitors of Akt activity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibitors of Akt activity will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4133154