Inhibitors of Akt activity

Details Inhibitors of Akt activity Inhibitors of Akt activity

2004-04-20

2009-12-29

Chang, Celia (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S300000, C514S301000, C514S302000, C546S113000, C546S114000, C546S115000, C546S118000

Reexamination Certificate

active

07638530

ABSTRACT:
The present invention is directed to compounds which contain a five-membered heterocyclic ring fused to a substituted pyridine moiety which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.

REFERENCES:
patent: 6060491 (2000-05-01), Pruitt et al.
patent: 6960584 (2005-11-01), Carling et al.
patent: 7223738 (2007-05-01), Bilodeau et al.
patent: 7399764 (2008-07-01), Duggan et al.
patent: 2002/0127214 (2002-09-01), Hemmings
patent: 2004/0102360 (2004-05-01), Barnett et al.
patent: 2004/0106540 (2004-06-01), Barnett et al.
patent: 2004/0116433 (2004-06-01), Owens et al.
patent: 2004/0122012 (2004-06-01), Owens et al.
patent: 2005/0130977 (2005-06-01), Lindsley et al.
patent: 2005/0159422 (2005-07-01), Lindsley et al.
patent: 2005/0182256 (2005-08-01), Duggan et al.
patent: 2005/0222155 (2005-10-01), Bilodeau et al.
patent: 2005/0288294 (2005-12-01), Duggan et al.
patent: WO 94/10171 (1994-05-01), None
patent: WO 96/11929 (1996-04-01), None
patent: WO 96/23769 (1996-08-01), None
patent: WO 96/23783 (1996-08-01), None
patent: WO 97/08167 (1997-03-01), None
patent: WO 97/22360 (1997-06-01), None
patent: WO 97/49704 (1997-12-01), None
patent: WO 01/66525 (2001-09-01), None
patent: WO 01/91754 (2001-12-01), None
patent: WO 02/083138 (2002-10-01), None
patent: WO 03/084473 (2003-10-01), None
patent: WO 2004/024728 (2004-03-01), None
Tessier et al. “Serum and glucocorticoid . . . ” J. Cell. Biochem. 98:1391-1407 (2006).
Webber et al. “the structures of the theinopyridine . . . ” J. Mol. Stru. 341:181-120 (1995).
King et al. “bioisosters, fonfomation . . . ” Med. Chem. principle and practice p. 206-209 (1994).
Patani et al. “Bioiossterism: a rational approach in drug design” Chem. Rve. v.96, p. 3147-3176 (1996).
Siebert “Das bioisosterie Konzept” Chemie in unserer Zeit, v.38(5) p. 320-324 (2004).
Kunick, et al. Database Caplus on Stn, J. Medicinal Chemistry, vol. 47(1), pp. 22-36, Abstract, 2004.
Barnett, et al. Database Calpus on Stn., Bioorganic & Medicinal Chemistry, vol. 26(11), pp. 1221-1226, Abstract, 2004.
DeFeo-Jones, et al. Molecular Cancer Therapeutics, vol. 4(2), p. 271-279 (2005).
Lindsley, et al. Bioorganic & Medicinal Chemistry Letters, vol. 15(3), p. 761-764 (2005).

Affiliated with

Also associated with

Rating

Inhibitors of Akt activity does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Inhibitors of Akt activity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibitors of Akt activity will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4074864