Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2011-03-22
2011-03-22
Hartley, Michael G (Department: 1618)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C514S210210, C514S249000, C514S263220, C514S314000, C536S029200, C544S277000, C544S350000, C546S173000
Reexamination Certificate
active
07910561
ABSTRACT:
The present invention is directed to compounds which contain substituted naphthyridines which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention. These substituted naphthyridines have unexpected advantageous properties when compared to other naphthyridines reported in PCT publication WO2003/086394, such unexpected advantageous properties may include increased cellular potency/solubility, greater selectivity, enhanced pharmacokinetic properties, lack of off target activity and so on.
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Arruda Jeannie M.
Bilodeau Mark T.
Campbell Brian T.
Cosford Nicholas D. P.
Hoffman Jacob M.
Hartley Michael G
Leff Matthew A.
Merck Sharp & Dohme Corp.
Muthard David A.
Rider Lance
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