Inhibitors of adenosine monophosphate deaminase

Details Inhibitors of adenosine monophosphate deaminase Inhibitors of adenosine monophosphate deaminase

1994-02-03

1998-03-24

Gupta, Yogendra N.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

514221, 540554, C07D49104

Patent

active

057314322

ABSTRACT:
Novel diazepine derivatives which selectively inhibit adenosine monophosphate deaminase and methods of preparing these compounds are provided. These compounds are useful in treating certain conditions in vivo which may be ameliorated by increased local concentrations of adenosine.

REFERENCES:
patent: 4935505 (1990-06-01), Townsend et al.
Danton, et al., "Isolation of Mutant Adenosine Deaminase by Coformycin Affinity Chromatography" Anal. Biochem. 159(1):233-239 (1986).
Omura, et al., "Manufacture of Novel Compound OM-3223 as Adenosine Deaminase Inhibitor for Therapeutic Use " Chem. Abstr. 107(9), Abract No. 76096 (1987).
Showalter, et al., "Studies Related to the Total Synthesis of Prntostatin: An Efficient, Regiospecific Glycosylation of Tetrahedron Lett. 22(33):3155-3158 (1981).

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