Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C544S134000, C548S125000, C548S128000, C549S059000, C549S068000

Reexamination Certificate

active

10850464

ABSTRACT:
The present invention relates to compounds with the formula (I)and also to pharmaceutical compositions comprising the compounds, as well as to the use of the compounds in medicine and for the preparation of a medicament which acts on the human 11-β-hydroxysteroid dehydrogenase type 1 enzyme.

REFERENCES:
patent: 3332942 (1967-07-01), Breivogel
patent: 1 277 729 (2003-01-01), None
patent: 822947 (1959-11-01), None
patent: 1053085 (1966-12-01), None
patent: 1240545 (1971-07-01), None
patent: WO 01/90090 (2001-11-01), None
patent: WO 01/90091 (2001-11-01), None
patent: WO 03/043999 (2003-05-01), None
patent: WO 03/044000 (2003-05-01), None
U.S. Appl. No. 10/302,329.
Small et al., Preventing local regeneration of glucocorticoids by 11βHSD1 enhances angiogenesis, PNAS, Aug. 23, 2005, vol. 102, No. 34, pp. 12165-12170, especially p. 12165.
Walker et al., 11βHSD1 as a novel therapeutic target in metabolic and neurodegenerative disease, Expert Opin. Ther. Targets, Mar. 17, 2004, vol. 7, No. 6, pp. 771-783, especially p. 771.
Ogg et al., The crystal structure of guinea pig 11βHSD1 provides a model for enzyme-lipid bilayer interactions, Feb. 4, 2005, vol. 280, No. 5, pp. 3789-3794, especially p. 3789.
Tomlinson et al., 11βHSD1: a tissue specific regulator of glucocorticoid response, Oct. 2004, vol. 25, No. 5, pp. 831-866, especially p. 831; Valsamakis, et al., 11βHSD1 activity in lean and obese males with type-2 diabetes mellitus, J. Clin. Endocrinol. Metab., Sep. 2004, vol. 89, No. 9, pp. 4755-4761, especially p. 4755.
Merck & Co., Merck Index; Monograph No. 4488 which discloses the antidiabetic compound N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide.
Stozowska et al., “Urinary silver and sulfathiazole levels in thermally injured guinea pigs during treatment with silver sulfathiazole cream,”S.T.P. Pharma Sciences, 1995, pp. 452-455, vol. 5.
Anton-Fos et al., “Pharmacological studies of the two new hypoglycemic compounds 4-(3-methyl-5-oxo-2-pyrazolin-1-yl)benzoic acid and 1-(mesitylen-2-sulfonyl)-1H-1,2,4-triazole,” STN International, File HCAPLUS, HCAPLUS accession No. 1995:311976, document No. 122:204545, 1994.
Avetisyan, et al., “Synthesis and Hypoglycemic activity of sulfonamide-1,3,4-thiadiazoles,” STN International, File HCAPLUS, HCAPLUS accession No. 1981-515404, document No. 95:115404, 1981.
Shoeb et al., “Possible oral hypoglycemic agents. III. Synthesis of some 3-amino-5-phenyl- and 5-amino-3-methyl-1,2,4-thiadiazole derivatives,” STN International, File HCAPLUS, HCAPLUS accession No. 1963:441726, document No. 59:41726, 1963.
Kivman et al., “Penetration of sulfanilamides into inflammatory foci,” STN International, File HCAPLUS, HCAPLUS accession No. 1982:484681, document No. 97:84681, 1982.
Scozzafava et al., “Carbonic anhydrase inhibitors: topically acting antiglaucoa sulfonamides incorporating phthaloyl and phthalimido moieties,” STN International, File HCAPLUS, HCAPLUS accession No. 2001:884365, document No. 136:160861, 2001.
Ingle et al., “Synthesis of 2-sulfanilamidotiazole derivatives and their antibacterial activity,” STN International, File HCAPLUS, HCAPLUS accession No. 1979:38829, document No. 90:38829, 1978.

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