Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1

Details Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1

2011-06-28

2011-06-28

Hui, San-ming (Department: 1628)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S424000, C548S408000, C548S543000

Reexamination Certificate

active

07968585

ABSTRACT:
The present invention discloses novel compounds of Formula (I): having 11β-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, and other conditions associated with 11β-HSD type 1 activity.

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