Inhibitors, obtained from bacilli, for glycoside hydrolases

Details Inhibitors, obtained from bacilli, for glycoside hydrolases Inhibitors, obtained from bacilli, for glycoside hydrolases

1977-12-06

1981-12-22

Hruskoci, Peter A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

435170, 435253, 435832, 435839, C12P 1712, C12P 104

Patent

active

043071945

ABSTRACT:
According to the present invention inhibitors for glycoside hydrolases, and in particular glucosidase inhibitors especially saccharase inhibitors, which are active in the digestive tract are formed by culturing organisms of the family Bacillaceae, particularly by strains of the genus Bacillus.
It has also been found that certain strains of organisms of the family Bacillaceae, especially strains DSM 7, DSM 704 and DSM 675 produce the antibiotic known as 1-desoxynojirimycin. The invention therefore provides a method of producing 1-desoxynojirimycin which comprises culturing a 1-desoxynojirimycin producing organism of the genus Bacillus. Inhibitors for glycoside hydrolases and the invention includes methods for producing such inhibitors, pharmaceutical compositions containing the inhibitors and methods of treatment involving the use of the inhibitors.

REFERENCES:
patent: 3940479 (1976-02-01), Shomura et al.
patent: 4013510 (1977-03-01), Frommer et al.
patent: 4019960 (1977-04-01), Frommer et al.
patent: 4065562 (1977-12-01), Ohata et al.
patent: 4137231 (1979-01-01), Murai et al.
patent: 4220782 (1980-09-01), Stoltefuss
Ishida et al., J. Antibiotics (Tokyo), Sera, 20, 66, 1967.
Inouye et al., Tetrahedron, 23, 2125-2144, 1968.

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