Inhibitors for urokinase receptor

Details Inhibitors for urokinase receptor Inhibitors for urokinase receptor

2005-03-29

2005-03-29

Brumback, Brenda (Department: 1653)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S015800, C530S317000, C530S323000, C530S333000, C530S344000

Reexamination Certificate

active

06872702

ABSTRACT:
The present invention concerns peptides as inhibitors of the binding of urokinase to the urokinase receptor. These peptides, which are preferably cyclic, are suitable as pharmaceutical agents for diseases that are mediated by urokinase and its receptor.

REFERENCES:
patent: WO 9422464 (1994-10-01), None
patent: 94 22464 (1994-10-01), None
patent: 95 14714 (1995-06-01), None
V. Magdolen et al., “Systematic mutational analysis of the receptor-binding region of the human urokinase-type plasminogen activator”, Eur. J. Biochem., vol. 237, 1996, pp. 237-251.
I. M. Takenaka et al., “Hsc70-binding Peptides Selected from a Phage Display Peptide Library that Resemble Organellar Targetting Sequences”, J. Biol. Chem, vol. 270, No. 34, 1995, pp. 19839-19844.
Kini et al. “A Common Structural Feature Enclosing Interaction Sites: Prediction of Protein—Protein Interaction Sites and Development of Potent Bioactive Peptides” Current Topics in Peptides and Protein Res., I (1994) pp 297-311.

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