Inhibitors for the formation of tumor necrosis factor

Details Inhibitors for the formation of tumor necrosis factor Inhibitors for the formation of tumor necrosis factor

1991-10-09

1994-04-19

Hill, Jr., Robert J.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530351, 435701, 4352402, C07K 300, C07K 1500, A01N 3718, C12P 2102

Patent

active

053046340

ABSTRACT:
The invention relates to inhibitors for the formation of tumor necrosis factor, processes for the preparation thereof by macrophages or mononuclear phagocytes which have been stimulated by lipopolysaccharides, and the use thereof for the treatment and prophylaxis of diseases caused by tumor necrosis factor.

REFERENCES:
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U. Schade et al., "Differences In Lipopolysaccharide-Induced Prostaglandin-Release And Phagocytic Activity Of Peritoneal Macrophages From LPS-Hyperreactive And Tolerant Mice," Natural Toxins, pp. 271-277 (D. Baker et al. eds., 1980).
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