Inhibitors for RNA viruses

Details Inhibitors for RNA viruses Inhibitors for RNA viruses

2005-08-02

2005-08-02

Housel, James (Department: 1648)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

C424S185100

Reexamination Certificate

active

06924353

ABSTRACT:
Human immunodeficiency virus inhibiting protein (HIVIP) has been isolated from a poisonous snake, the Australian Taipan, Oxyuranus Scutellatus. HIVIP is characterized as a potent inhibitor of HIV-1 and HIV-2 viruses in cell culture. HIVIP is characterized as a stable, non toxic component of venom, having molecular weight 13,500 Daltons revealed by gel electrophoresis. The partial sequence of HIVIP for its first fifteen N-terminal amino acids is given by SEQ. ID. No: 1:Asn Leu Ala Gln Phe Gly Phe Met Ile Arg Cys Ala Asn Gly Gly.The active domain of HIVIP was isolated and determined to be SEQ. ID. NO.: 2:Ala Lys Ala Gly Ser Asp Asn Thr Lys Gly Gly Val Try Pro Met Phe Gly Met.Various peptides containing at least a portion of this sequence from the N-terminal have been shown to inhibit other RNA viruses in cell culture and are collectively termed RIPs, RNA virus Inhibitor Peptides. Such peptides can be made in abundance and cheaply to provide a synthetic therapeutic for the infections caused by RNA viruses.

REFERENCES:
Lipps, Binie, Isolation of subunits α, β and γ of the complex taipoxin from the venom ofOxyuranus s. scutellatus, Toxicon, 2000, 38:1845-1854.

Affiliated with

Also associated with

Rating

Inhibitors for RNA viruses does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Inhibitors for RNA viruses, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibitors for RNA viruses will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3497198