Inhibitors for de novo-RNA polymerases and methods of...

Details Inhibitors for de novo-RNA polymerases and methods of... Inhibitors for de novo-RNA polymerases and methods of...

2005-06-14

2005-06-14

Berch, Mark L. (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen bonded directly to ring carbon of the purine ring...

C544S265000, C544S277000, C536S027600, C536S027610

Reexamination Certificate

active

06906190

ABSTRACT:
A polymerase inhibitor has first moiety coupled to a second moiety via an optional linker in which the first moiety binds to an initiation nucleotide binding site of a polymerase and forms at least two hydrogen bonds with an RNA template strand that is associated with the polymerase, and in which the second moiety comprised a compound that binds to a site proximal to the nucleotide binding site of the polymerase and thereby increases the affinity of the polymerase inhibitor to the polymerase.

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