Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1991-07-15
1993-04-27
Brown, Johnnie R.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
435200, 536 41, C07H 1502, A61K 3170, C12N 910, C12Q 148
Patent
active
052063569
ABSTRACT:
Synthetic glycosaminosyl transferase-V acceptors and inhibitors are disclosed. Minimal trisaccharide inhibitors and acceptors specific for GnT-V, which is associated with the ability of cells to metastasize are useful, in diagnosis and treatment of conditions characterized by metastatic cells.
REFERENCES:
patent: 4770994 (1988-09-01), Rittenhouse
patent: 5032505 (1991-07-01), Pierce et al.
Ahrens et al. J. Biol. Chem. 262:7575 (1987).
Camarasa et al.; J. Med. Chem. 28:40 (1985).
Cummings et al.; J. Biol. Chem. 257:11230 (1982).
Dennis; Cancer Res. 46:5131 (1986).
Dennis; Cancer Surveys (1988).
Dennis et al., Science 236:582 (1987).
Humphries et al.; Science 233:467 (1986).
Irimura et al.; Cancer Res. 41:3411 (1981).
Kijima-Suda et al.; Cancer Res. 46:858 (1986).
Pierce et al.; J. Biol. Chem. 261:10772 (1986).
Schacter; Biochem. Cell. Biol. 64:163 (1986).
Vaghefi et al.; J. Med. Chem. 30:1391 (1987).
Yamashida et al.; J. Biol. Chem. 259:10834 (1984).
Yamashida et al.; J. Biol. Chem. 260:3963 (1985).
Srivastava et al.; Carb. Res. 179:137-161 (1988).
Palcic et al.; Glycoconjugate J. 5:49-63 (1988).
Hindsgaul Ole
Pierce James M.
Brown Johnnie R.
Carson Nancy S.
Chembiomed Ltd.
LandOfFree
Inhibitors for alpha-L-fucosyl transferase does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Inhibitors for alpha-L-fucosyl transferase, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibitors for alpha-L-fucosyl transferase will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2328445