Inhibitor oligonucleotides and their use for specific...

Details Inhibitor oligonucleotides and their use for specific... Inhibitor oligonucleotides and their use for specific...

2008-05-13

2008-05-13

Angell, Jon E. (Department: 1635)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C536S023100, C536S024500, C435S006120, C435S375000

Reexamination Certificate

active

10494800

ABSTRACT:
A method of treating a disease resulting from the expression of a harmful gene is described. The method includes the step of administering a therapeutically effective amount of a pharmaceutical composition having at least one double stranded oligonucleotide including two complementary oligonucleotide sequences forming a hybrid. Each oligonucleotide sequence comprises at one of their 3′ or 5′ ends one to five unpaired nucleotides forming single-strand ends extending beyond the hybrid. One of the oligonucleotide sequences is substantially complementary to a target sequence belonging to a DNA or messenger RNA molecule of a gene coding a mutated or nonmutated androgen receptor.

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