Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1997-01-21
1999-01-19
Walsh, Stephen
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
514 2, C07K 1400, A61K 3802
Patent
active
058614842
ABSTRACT:
The vascula endothelial cell growth factor (VEGF) inhibitors of the present invention are naturally occurring or recombinantly engineered soluble forms with or without a C-terminal transmembrane region of the receptor for VEGF, a very selective growth factor for endothelial cells. The soluble forms of the receptors will bind the growth factor with high affinity but do not result in signal transduction. These soluble forms of the receptor bind VEGF and inhibit its function.
REFERENCES:
Shibuya et al., Oncogene, 5, 519-524, 1990.
Duan et al., J. Biol. Chem., 266, 413-418, Jan. 1991.
Terman et al., Biochem and Biophysical Res. Commun., 187, 1579-1586, Sep. 1992.
Terman et al., On Cogene, 6, 1677-1683, 1991.
Conn et al., Amino acid and cDNA sequences of a vascular endothelial cell mitogen that is homologous to platelet-derived growth factor, (1990) Proc. Natl. Acad. Sci. U.S.A., 87, pp. 2628-2632.
Ferrara and Henzel, Pituitary Follicular Cells Secrete A Novel Heparin-Binding Growth Factor Specific For Vascular Endothelial Cells, (1989) Biochem. Biophys. Res. Comm., 161, pp. 851-858.
Gozpadorowicz et al., Isolation and characterization of a vascular endothelial cell mitogen produced by pituitary-derived folliculo stellate cells, (1989) Proc. Natl. Acad. Sci. U.S.A., 86 pp. 7311-7315.
Connolly, D.T. et al., Vascular Permeability Factor, an Endothelial Cell Mitogen Related to PDGF, (1989) Science, 246 pp. 1309-1312.
DeVries, C. et al., The fms-Like Tyrosine Kinase, a Receptor for Vascular Endothelial Growth Factor, (1992) Science 255 pp. 989-991.
Terman, B.I. et. al., Identification of a new endothelial cell growth factor receptor tyrosine kinase, (1991) Oncogene 6, pp. 1677-1683.
Terman, B.I. et. al., Identification of the KDR Tyrosine Kinase As A Receptor For Vascular Endothelial Cell Growth Factor, (1992) Biochem. Biophys. Res. Comm., 187, pp. 1579-1586.
Shibuya, M. et. al., Nucleotide Sequence and expression of a novel human receptor-type tyrosine kinase gene (fit) closely related to the fms family, (1990) Oncogene, 5, pp. 519-524.
Duan, D-S. R. et. al., A Functional Soluble Extracellular Region of the Platelet-derived Growth Factor (PDGF) B-Receptor Antagonizes PDGF-stimulated Responses, (1991) J. Biol. Chem., 266, pp. 413-418.
Hoshi, H. and McKeehan, Brain- and liver cell-derived factors are required for growth of human endothelial cells in serum-free culture, (1984) Proc. Natl. Acad. Sci. U.S.A., 81 pp. 6413-6417.
Sanger et. al., DNA sequencing with chain-terminating inhibitors, (1977) P.N.A.S. USA, 74 pp. 5463-5467.
Feinberg, A.P. and Vogelstein, B., A. Technique for Radiolabeling DNA Restriction Endonuclease Fragments to High Specific Activity, (1983) Anal. Biochem., 132, pp. 6-13.
Hunter, W.M. and Greenwood, F.C., Preparation of Iodine-131 Labelled Human Growth Hormone of High Specific Activity, (1962) Nature (London), 194, pp. 495-496.
Scatchard, G., The Attractions Of Proteins For Small Molecules and Ions, (1949) Ann. N.Y. Acad. Sci., 51, pp. 660-672.
Bikflevi, A. et al., Interaction of Vasculotropin/Vascular Endothelial Cell Growth Factor With Human Umbilical Vein Endothelial Cells; Binding, Intemalization, Degradation, and Biological Effects, (1991) Journal of Cellular Physiology, 149, pp. 50-59.
Olsson, I. et al., The receptors for regulatory molecules of hematopoieses, (1992) Eur J. Haematol, 48 (1), pp. 1-9.
Kendall Richard L.
Thomas, Jr. Kenneth A.
Basi Nirmal S.
Hand J. Mark
Merck & Co. , Inc.
Tribble Jack L.
Walsh Stephen
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