Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1992-04-29
1994-05-24
Hill, Jr., Robert J.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530395, C07K 1300
Patent
active
053149947
ABSTRACT:
A biological reagent and diagnostic system for the detection and quantitation of endothelial plasminogen activator inhibitor (PAI) are disclosed, as are substantially pure, recombinant human endothelial PAI, its biologically pure gene and a vector for cloning the gene and expressing a gene product.
REFERENCES:
patent: 4235960 (1980-11-01), Sasse et al.
patent: 4766075 (1988-08-01), Goeddel et al.
patent: 5134065 (1992-07-01), Sanzo et al.
Nielsen et al., FEBS, 196(2):269-273 (Feb. 1986).
Chemical Abstracts: 106(15):114590e, (Apr. 13, 1987), (p. 166), [Wun et al., FEBS Letters, 210(1):11-16, (1987)].
Sawdey et al., Federation of American Societies for Experimental Biology, 44(5):1656, (1985), Abstract No. 7281.
Ginsburg et al., J. Clin. Invest., 78, Dec. 1986, pp. 1673-1680.
Sprengers et al., "Evidence for the Presence of Two Different Fibrinolytic . . . ", BBA 801, 163-170, Oct. 1984.
Dictionary of Microbiology and Molecular Biology, 2nd ed., Singleton and Sainsbury, John Wiley & Sons, New York, p. 374.
Sprengers et al., Thrombosis and Haemostasis, 55(3):325-329 (1986).
Thrombosis and Haemostasis, 56(3):415-416 (1986).
Hekman et al., J. Biol. Chem., 260(21):11581-11587 (1985).
Schleef et al., J. Cell. Phys., 134:269-274 (1988).
Mimuro et al., Nucl. Acids. Res., 17(21):8872 (1989).
Kurachi et al., Proc. Natl. Acad. Sci., USA, 78:6826-6830 (1981).
Erickson et al., Proc. Natl. Acad. Sci., USA, 82:8714 (1985).
Erickson et al., J. Clin. Invest., 74:1465-1472 (1984).
Sprengers et al., Biochim. Biophys. Acta, 801:163-170 (1984).
Ny et al., Proc. Natl. Acad. Sci. USA, 83:6776-6780 (1986).
Pannekoek et al., The EMBO J., 5(10):2539-2544 (1986).
Sawdey et al., Throm. Res., 41:151-160 (1986).
Rogers et al., Biochem. and Biophys. Res. Comm., 116(2):375-382 (1983).
Ny et al., Proc. Natl. Acad. Sci. USA, 81:5355-5359 (1984).
van Mourik et al., J. Biol. Chem., 259(23):14914-14921 (1984).
R. Loskutoff et al., "Detection of an Unusually Stable Fibrinolytic Inhibitor . . . ", Proc. Natl. Acad. Sci. USA, vol. 80, pp. 2956-2960 May 1983.
van Mourik et al., "Purification of an Inhibitor of Plasminogen Activator . . . ", J. Biol. Chem., vol. 259(23), pp. 14914-14921, Dec. 10, 1983.
Young et al., "Efficient Isolation of Genes Using Antibody Probes", Proc. Natl. Acad. Sci. USA, vol. 80, pp. 1194-1198 Mar. 1983.
Loskutoff David J.
Ny Tor
Sawdey Michael
Allen Marianne Porta
Hill Jr. Robert J.
Scripps Clinic and Research Foundation
LandOfFree
Inhibitor of tissue-type and urokinase-type plasminogen activato does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Inhibitor of tissue-type and urokinase-type plasminogen activato, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibitor of tissue-type and urokinase-type plasminogen activato will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1973663