Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1993-01-25
1994-10-18
Kepplinger, Esther M.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
5303893, 53038825, 435 792, 436548, C07K 1528, G01N 33535, G01N 33577, A61K 39395
Patent
active
053567838
ABSTRACT:
A sulfated glycoprotein with a molecular weight of approximately 45 kda inhibits the activation of tissue factor and thus inhibits the coagulation of blood. This glycoprotein can be used for treatment or prevention of intravascular clotting.
REFERENCES:
patent: 4966852 (1990-10-01), Wun et al.
patent: 5219994 (1993-06-01), Buonassisi et al.
Warn-Cramer et al, 1987, Partial Purification and Characterization of Extrinsic Pathway Inhibitor (the Factor Xa-Dependent Plasma Inhibitor of Factor VIIa/Tissue Factor). Thrombosis Res 48:11-22.
Warn-Cramer et al, 1992, Purification of Tissue Factor Pathway Inhibitor (TFPI) from Rabbit Plasma and Characterization of its Differences from TFPI Isolated from Human Plasma, Thrombosis Res 67: 367-83.
Wun et al. "Cloning and Characterization of a cDNA Coding for the Lipoprotein-associated Coagulation Inhibitor Shows That it Consists of Three Tandem Kunitz-type Inhibitory Domains" J. Biol. Chem. 263(13):6001-6004 (1988).
Colburn et al. "Enhanced Inhibition of Tissue Factor by the Extended Form of an Endothelial Cell Cell Glycoprotein (an Extrinsic Pathway Inhibitor)" J. Cell. Physiol. 140:320-326 (1991).
Hjort "Anti Convertin" Scand. J. Clin Lab. Invest vol. 9, Suppl 27, pp. 76-97.
Broze et al. Proc Natl Acad Sci USA 84: 1886-1890 (1987).
Buonassisi Vincenzo
Colburn Patricia C.
Grun James L.
Kepplinger Esther M.
W. Alton Jones Cell Science Center, Inc.
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