Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1994-08-16
1995-06-27
Wax, Robert A.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4351723, 4352523, 4352402, 4353201, 536 235, 935 11, 935 27, 935 56, 935 66, C12N 1515, C12N 1510, C12N 121, C12N 1563
Patent
active
054279267
ABSTRACT:
A sulfated glycoprotein with a molecular weight of approximately 45 kda inhibits the activation of tissue factor and thus inhibits the coagulation of blood. This glycoprotein can be used for treatment or prevention of intravascular clotting.
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patent: 5219994 (1993-06-01), Buonassisi et al.
Hjort, "Anti-Convertin" Scand. J. Clin. Lob: Invest (Suppl.27):76-97.
Broze et al., "Isolation of the Tissue Factor Inhibitor Produced by HepG2 Hepatoma Cells" Proc. Natl. Acad. Sci. USA 84:1886-1890 (1987).
Wun et al. "Cloning and Characterization of a cDNA Coding for the Lipoprotein-associated Coagulation Inhibitor Shows That it Consists of Three Tandem Kunitz-type Inhibitory Domains" J. Biol. Chem. 263(13):6001-6004 (1988).
Colburn et al., "Enhanced Inhibition of Tissue Factor by the Extended Form of an Endothelial Cell Glycoprotein (an Extrinsic Pathway Inhibitor)" J. Cell. Physiol. 140:320-326 (1991).
Warn-Cramer, B. J. et al., "Partial Purification and Characterization of Extrinsic Pathway Inhibitor (The Factor Xa-Dependent Plasma Inhibitor of Factor VIIa/Tissue Factor)", Thrombosis Research 48:11-22 (1987).
Warn-Cramer, B. J. et al., "Purification of Tissue Factor Pathway Inhibitor (TFPI) From Rabbit Plasma and Characterization of its Differences from TFPI Isolated From Human Plasma" Thrombosis Research 67:367-383 (1992).
Buonassisi Vincenzo
Colburn Patricia C.
Prouty Rebecca
W. Alton Jones Cell Science Center, Inc.
Wax Robert A.
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