Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1994-09-30
2000-02-08
Carlson, Karen Cochrane
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530385, C07K 14795, C07K 14805
Patent
active
060228482
ABSTRACT:
Disclosed and claimed are methods for the isolation and use of stem cell inhibiting factors for regulating the abnormal stem cell cycle and for accelerating the post-chemotherapy peripheral blood cell recovery. Also disclosed and claimed are the inhibitors of stem cell proliferation.
REFERENCES:
patent: 4350683 (1982-09-01), Galfre et al.
patent: 4683194 (1987-07-01), Saiki et al.
patent: 5028588 (1991-07-01), Hoffman et al.
patent: 5239061 (1993-08-01), Fronticelli et al.
patent: 5449759 (1995-09-01), Hoffman et al.
Swanson, et al, Bio/Technology, vol. 10, p. 557-559, May 1992, "Production of functional human hemoglobin in transgenic swine".
Kriegler, A.B., et al, Exp. Hematol., vol. 9, No. 1, pp. 11-21, Jan. 1981 "Identification of the "Factor" in Erythrocyte Lystes Which Enhances Colony Growth in Agar Cultures".
Moqattash, S., et al, Acta Haematol, 1994; 92:182-186, "Hemopoietic Recovery from AZT Toxicity with Recombinant Hemoglobin in a Murine Model of AIDS".
Petrov, Rem V., et al, Bioscience Reports, vol. 15, No. 1, 1995 "Myelopeptides: Bone Marrow Regulatory Mediators".
Shaeffer, J.R., The Journal of Biological Chemistry, vol. 269, No. 47, Issue of Nov. 25, 1994, pp. 29530-29536, "Heterogeneity in the Structure of the Ubiquitin Connugates of Human .alpha. Globin".
Karelin, A.A., et al, Peptides, vol. 16, No. 4, pp. 693-697, 1995 "Proteolytic Degradation of hemoglobin in Erythrocytes Leads to Biologically Active Peptides".
Mueller, S., et al, Blood, 1995 Nov 15;86(10):1974-1974 "Purified Adult Hemoglobin Stimulates the Proliferation and Differentiation of Erythroid Progenitors".
Dunlop et al, Blood, vol. 79, No. 9, issued May 1, 1992, pp. 2221-2225 "Demonstration of Stem Cell Inhibition and Myeloprotective Effects of SCI/rhMIP1 alpha in vivo".
Davatelis et al, Journal of Experimental Medicine, vol. 157, issued Jun. 1988, pp. 1939-1944 "Cloning and Characterization of a cDNA for Murine Macrophage Inflammatory Protein (MIP), a Novel Monokine with Inflammatory and Chemokinetic Properties".
Hunkapiller et al, Methods in Enzymology, vol. 91, issued 1983, pp. 227-236 "Isolation of Microgram Quantities of Proteins from Polyacrylamide Gels for Amino Acid Sequence Analysis".
Lathe, Journal of Molecular Biology, vol. 183, issued 1985, pp. 1-12 "Synthetic Oligonucleotide Probes Deduced from Amino Acid Sequence Data. Theoretical and Practical Consideratons".
Ohtsuka et al, Journal of Biological Chemistry, vol. 260, No. 5, issued Mar. 10, 1985, pp. 2605-2608 "An Alternative Approach to Deoxyoligonucleotides as Hybridization Probes by Insertion of Deoxyinosine at Ambiguous Codon Positions".
"Mechanisma That Regulate the Cell Cycle Status of Very Primitive Hematopoietic Cells in Long-term Human Marrow Cultures. II. Analysis of Positive and Negative Regulators Produced by Stromal Cells Within the Adherent Layer"by Eaves et al. 78 Blood110-117 (1991).
"An Inhibitor of Stem Cell Proliferation in Normal Bone Marrow"by Lord et al. 34 British Journal of Haematology441-445 (1976).
"Sources of Haemopoietic Stem Cell Proliferation: Stimulators and Inhibitors"by Lord et al. 6 Blood Cells581-593 (1980).
"Identification and Characterization of an Inhibitor of Haemopoietic Stem Cell Proliferation"by Graham et al. 344 Nature442-444 (1990).
"Macrophages Secrete A Novel Heparin-binding Protein With Inflammatory and Neutrophil Chemokinetic Properties" by Wolpe et al. 167 J. Exp. Med. 570-581 (1988).
"Macrophage Inflammatory Protein--1: A Prostaglandin-independent Endogenous Pyrogen" by Davatelis et al. 243 Science 1066-1068 (1989).
"The Cellular Specificity of Haemopoietic Stem Cell Proliferation Regulators" by Tejero et al. 50 Br. J. Cancer 335-341 (1984).
"Myelopoietic Enhancing Effects of Murine Macrophage Inflammatory Proteins 1 and 2 on Colony Formation In Vitro by Murine and Human Bone Marrow Granulocyte/Macrophage Progenitor Cells" by Broxmeyer et al. 170 J. Exp. Med. 1583-1593 (1989).
"Loss of Immunoreactivity in Long-term Bone Marrow Culture" by Mundy et al. 275 Nature 135-136 (1978).
"Clinical Significance of Long-term Cultures of Myeloid Blood Cells" by Eaves et al. 7 CRC Critical Reviews in Oncolcogy/Hematology 125-138 (1987).
"The Therapeutic Potential of Long-term CML Marrow Cultures" by Eaves et al. The Biology of Hematopoiesis.
"Improvement of Leukemic LTBMC Establishment by Using Specific Inhibitor of Hematopoietic Stem Cell Proliferation" Tsyrlova et al. Leukemia: Advances in Biology and Therapy 35 (1988).
"A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells" by Till et al. 14 Radiation Research 213-222 (1961).
"The Effect of Differing Demands for Blood Cell Production on DNA Synthesis by Hemopoietic Colony-forming Cells of Mice" by Becker et al. 26 Blood 296-308 (1965).
"Effect of Steroids on the Cycling of Haemopoietic Stem Cells" by Bryon 228 Nature 1204 (1970).
"Inhibitor of Haemopoietic CFU-S Proliferation: Assays, Production Sources and Regulatory Mechanisms" by Lord et al. 162 The Inhibitors of Hematopoiesis 227-239 (1987).
"Macrophage-Inflammatory Protein Protects Multipotent Hematopoietic Cells from the Cytotoxic Effects of Hydroxyurea In Vitro" by Lord et al. 79 Blood 2605-2608 (1992).
"Most Primitive Hematopoietic Stem Cells are Stimulated to Cycle Rapidly After Treatment with 5-Fluorouracil" by Harrison et al. 78 Blood 1237-1240 (1991).
"The Regulation of Hemopoiesis Long-term Bone Marrow Cultures. II. Stimulation and Inhibition of Stem Cell Proliferation" by Toksoz et al. 55 Blood 931-936 (1980).
"Isolation of Spleen-colony Forming Cells (CFU-s) Using Wheat Germ Agglutinin and Rhodamine 123 Labeling" by Visser et al. 14 Blood Cells 369-384 (1988.
"In Vitro Analysis of Murine B-Cell Development" by Whitlock et al. 3 Ann. Rev. Immunol. 213-35 (1985).
"Maintenance and Proliferation Control of Primitive Hemopoietic Progenitors in Long-term Cultures of Human Marrow Cells" by Eaves et al. 14 Blood Cells 355-368 (1988).
"Allogeneic Bone Marrow Transplantation Using Unrelated Donors: A Pilot Study of the Canadian Bone Marrow Transplant Group" by Phillips et al. 8 Bone Marrow Transplantation 477-487 (1991).
Kozlov Vladimir
Tsyrlova Irena
Carlson Karen Cochrane
Pro-Neuron, Inc.
LandOfFree
Inhibitor of stem cell proliferation and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Inhibitor of stem cell proliferation and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibitor of stem cell proliferation and uses thereof will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1681530