Inhibitor of ribonucleotide reductase

Details Inhibitor of ribonucleotide reductase Inhibitor of ribonucleotide reductase

1987-05-22

1989-07-04

Moskowitz, Margaret

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

4 to 5 amino acid residues in defined sequence

530324, 530325, 530326, 530327, 530328, 530329, 514 15, 514 17, 514 14, 514 16, 435184, C07K 706, C12N 999, A61K 3702

Patent

active

048451959

ABSTRACT:
The pentapeptide Val Val Asn Asp Leu has been found to be the shortest peptide sequence that inhibits the activity of the ribonucleotide reductase enzyme of herpes simplex virus in vitro thereby inhibiting viral replication. Longer peptides containing the foregoing pentapeptide sequence are more potent inhibitors.

REFERENCES:
Dutia et al., "Specific Inhibition of Herpesvirus ribonucleotide reduct ase by synthetic Peptides", Nature, vol. 321, pp. 439-441 (1986).
Cohen et al., "Specific Inhibition of Herpesvirus ribonucleotide reduct ase by a Nonapeptide Derived from the Carboxy terminus of Subunit 2", Nature, vol. 321, pp. 441-443 (1986).
Gaudreau et al., "Structure Activity Studies on Synthetic Peptides Inhibiting Herpes Simplex Virus ribonucleotide reductase", J. Biol. Chem., vol. 262, #26, pp. 12413-12416 (1987).

Affiliated with

Also associated with

Rating

Inhibitor of ribonucleotide reductase does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Inhibitor of ribonucleotide reductase, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibitor of ribonucleotide reductase will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-853555