Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 6 to 7 amino acid residues in defined sequence
Patent
1987-05-22
1989-03-21
Moskowitz, Margaret
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
6 to 7 amino acid residues in defined sequence
530327, 530328, 530330, 514 23, 514575, 4351723, C07K 706, C07K 708
Patent
active
048144320
ABSTRACT:
A series of peptides has been found to inhibit the activity of the ribonucleotide reductase enzyme of herpes simplex virus in vitro thereby inhibiting viral replication.
REFERENCES:
Dutia et al., "Specific Inhibition of Herpesvirus Ribonucleotide Reductose by Synthetic Peptides," Nature, vol. 321, pp. 439-441 (1986).
Cohen et al., "Specific Inhibition of Herpesvirus Ribone Cleotide Reductose by a Nonapeptide Derived from the Carboxy Tervavirus of Sub Unit 2" Nature, vol. 321, pp. 441-443 (1986).
Gaudreau et al., "Structure Activity Studies on Synthetic Peptides Inhibiting Herpes Simplex Virus Siborucleotide Reductose," J. Biol. Chem., vol. 262, #26, pp. 12413-12416 (1987).
Freidinger Roger
Garsky Victor M.
Hannah John
Stein Robert B.
Tolman Richard L.
Chow Frank S.
Merck & Co. , Inc.
Mohamed Abdez A.
Moskowitz Margaret
Perrella Donald J.
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