Inhibitor of ribonucleotide reductase

Details Inhibitor of ribonucleotide reductase Inhibitor of ribonucleotide reductase

1987-05-22

1989-06-06

Moskowitz, Margaret

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

8 to 10 amino acid residues in defined sequence

530324, 530325, 530326, 530327, 530329, 530330, 514 15, 514 17, 435184, C07K 706, C12N 999, A61K 3702

Patent

active

048373044

ABSTRACT:
A series of oligopeptides each of which contains a D-amino acid has been found to inhibit the activity of the ribonucleotide reductase enzyme of herpes simplex virus in vitro thereby inhibiting viral replication.

REFERENCES:
Dutia et al, "Specific Inhibition of Herpes Virus Ribonucleotide Reductase by Synthetic Peptides", Nature, vol. 321, pp. 439-441 (1986).
Cohen et al, "Specific Inhibition of Herpes Virus Ribonucleotide Reductase, by a Nonapeptide Derived from the Carboxy Terminus of Subunit 2", Nature, vol. 321, pp. 441-443 (1986).
Gaudreau et al, "Structure Activity Studies on Synthetic Peptides Inhibiting Herpes Simplex Virus Ribonucleotide Reductase", Jour. Biol. Chem., vol. 262, #26, pp. 12413-12416 (1987).

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