Inhibitor of NF-KB activation

Details Inhibitor of NF-KB activation Inhibitor of NF-KB activation

2000-09-28

2010-06-29

O Hara, Eileen B (Department: 1638)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C530S387100, C530S387300, C530S387900, C530S388100, C536S023500, C536S023530

Reexamination Certificate

active

07745579

ABSTRACT:
The present invention relates to a protein, designated NAP (Nemo Associated Protein), that was discovered to inhibit the activation of transcription factor NF-kB by various signals that are important in inflammatory and immune processes. The DNA and the recombinant production of this protein is also disclosed as well as methods of using the protein or encoding DNA.

REFERENCES:
patent: 2005/0003447 (2005-01-01), Lal et al.
patent: 96 25941 (1996-08-01), None
patent: 96 36730 (1996-11-01), None
patent: 97 15586 (1997-05-01), None
patent: 97 45542 (1997-12-01), None
patent: WO 99/47672 (1999-09-01), None
patent: 0017355 (2000-03-01), None
Ghosh and Karin. Missing pieces in the NF-kB puzzle. Apr. 2002. Cell 109: S81-S96.
Baldwin. The transcription factor NF-kB and human disease. Jan. 2001. The Journal of Clinical Investigation 107:3-6.
Everett et al. Pendred syndrome is caused by mutations in a putative sulphate transporter gene (PDS). Nature Genetics 17: 411-422, 1997.
Scott et al. The pendred syndrome gene encodes a chloride-iodide trasnport protein. Nature Genetics 21: 440-443, 1999.
Berendsen H.J.C. A glimpse of the Holy Grail? Science 282: 642-643, 1998.
Bignell et al. Nature Genetics 25: 160-165, Jun. 2000.
Nagase et al. DNA Research 5: 355-364, Dec. 1998.
Stratton, M.R., Genbank submission AJ250014, 3 pages, Nov. 29, 1999.
USPTO Sequence Search, Result 7 from .rge database, pp. 12-14.
Rothwarf et al., “IKK- is an essential regulatory subunit of the IKB kinase complex”,Nature, (1998) vol. 395, No. 17, pp. 297-300.
Yamaoka et al., “Complementation Cloning of NEMO, a Component of the IKB Kinase Complex Essential for NF-KB Activation”,Cell, (1998), vol. 93, pp. 1231-1240.
Li et al., “Identification of a cell protein (FIP-3) as a modulator of NF-KB activity and as a target of an adenovirus inhibitor of tumor necrosis factor α-induced apoptosis”,Proc. Natl. Acad. Sci, USA, vol. 96, pp. 1042-1047.
Li et al., “Interaction of an Adenovirus E3 14.7-Kilodalton Protein with a Novel Tumor Necrosis Factor Alpha-Inducible Cellular Protein Containing Leucine Zipper Domains”,Molecular and Cellular Biology, (1998), vol. 18, No. 3, pp. 1601-1610.
May et al, “Signal transduction through NF-kappaβ”,Immunology Today19:80-88(1998).
“Homo sapiensmRNA for KIAA0849 protein, partial cds”,EMBL Nucleotide SequenceXP-002108972 (Feb. 9, 1999).
Ye et al. “The structural basis for the recognition of diverse receptor sequences by TRAF2” Molecular Cell, 4:321-330 (1999).

Affiliated with

Also associated with

Rating

Inhibitor of NF-KB activation does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Inhibitor of NF-KB activation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibitor of NF-KB activation will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4159776