Inhibitor of inflammatory cytokine formation comprising polypren

Details Inhibitor of inflammatory cytokine formation comprising polypren Inhibitor of inflammatory cytokine formation comprising polypren

1996-05-31

1998-01-13

Henley, III, Raymond

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

C-o-group doai

514547, A61K 3105, A61K 31225

Patent

active

057080372

ABSTRACT:
Polyprenyl derivatives having the general formula as the active ingredient: ##STR1## where R.sup.1 and R.sup.2 are the same or different, and each represents a hydrogen atom, a C.sub.1 -C.sub.4 alkyl group, a C.sub.2 -C.sub.12 aliphatic acyl group, a C.sub.7 -C.sub.11 aromatic acyl group or a C.sub.8 -C.sub.12 aryl-substituted aliphatic acyl group; and n represents an integer from 0 to 2, show excellent activity in the inhibition of the formation of inflammatory cytokines, and they exhibit an excellent therapeutic effect on inflammatory bowel diseases such as ulcerative colitis, Crohn's disease and Behcet syndrome.

REFERENCES:
patent: 4192953 (1980-03-01), Mishima et al.
patent: 4434179 (1984-02-01), Kobayashi et al.

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