Inhibitor of inflammatory cytokine formation comprising polypren

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – C-o-group doai

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514547, A61K 3105, A61K 31225

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active

057080372

ABSTRACT:
Polyprenyl derivatives having the general formula as the active ingredient: ##STR1## where R.sup.1 and R.sup.2 are the same or different, and each represents a hydrogen atom, a C.sub.1 -C.sub.4 alkyl group, a C.sub.2 -C.sub.12 aliphatic acyl group, a C.sub.7 -C.sub.11 aromatic acyl group or a C.sub.8 -C.sub.12 aryl-substituted aliphatic acyl group; and n represents an integer from 0 to 2, show excellent activity in the inhibition of the formation of inflammatory cytokines, and they exhibit an excellent therapeutic effect on inflammatory bowel diseases such as ulcerative colitis, Crohn's disease and Behcet syndrome.

REFERENCES:
patent: 4192953 (1980-03-01), Mishima et al.
patent: 4434179 (1984-02-01), Kobayashi et al.

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