Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Reexamination Certificate
2011-07-05
2011-07-05
Shafer, Shulamith H (Department: 1647)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
C530S350000
Reexamination Certificate
active
07973133
ABSTRACT:
The invention relates to an inhibitor of endogenous human interferon-gamma (hIFN-ϝ) in autoimmune diseases, especially in multiple sclerosis. More precisely, the invention relates to inactivated protein derivatives of the hIFN-ϝ with preserved affinity to the hIFN-ϝ receptor. The derivatives represent genetically modified variants of hIFN-ϝ where the C-terminal part of the molecule is either deleted or replaced with a polypeptide sequence of another human protein and a recombinant hIFN-ϝ inactivated by physical or chemical methods.
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patent: 6548056 (2003-04-01), Presnell et al.
patent: WO 94/12531 (1994-06-01), None
patent: WO 00/43033 (2000-07-01), None
Luk et al. 1990. J. Biol. Chem. 265:13314-13319.
Human interferon alpha in UniProtKB, http://www.uniprot.org/uniprot/?query=human+interferon+alpha&sort=score, downloaded Sep. 15, 2010.
Nacheva Genoveva et al. “Human Interferon Gamma: Significance of the C-Terminal Flexible domain for its biological activity.” Archives of Biochemistry and Biophysics, vol. 413, No. 1, May 1, 2003, pp. 91-98.
Grigoleit Hans-Guenther
Gunther Rolf
Ivanov Ivan
Nacheva Genoveva
Tsanev Rumen
Jacobson & Holman PLLC
Shafer Shulamith H
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