Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1979-11-30
1981-03-24
Randolph, John D.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
26023975, 260465E, 544325, A61K 31505, C07D23949, C07D23949
Patent
active
042580455
ABSTRACT:
A group of aryl-Z-alkoxy-5-benzylpyrimidines wherein Z is oxy, thio, imino, carbonyl, carbamoyl, sulfonyl, sulfinyl or sulfamoyl has been prepared from 2,4-diamino-5-benzylpyrimidine via alkylation with either an aryl-Z-alkyl halide or a substituted glycidyl ether. These compounds are potent dihydrofolate reductase (DHFR) inhibitors which are useful as antibacterial, anti-protozoal and antitumor agents.
REFERENCES:
patent: 2909522 (1959-10-01), Hitchings et al.
patent: 3049544 (1962-08-01), Stenbuck et al.
patent: 3692787 (1972-09-01), Roth et al.
patent: 3931181 (1976-01-01), Kompis et al.
patent: 3992379 (1976-11-01), Liebenow et al.
Lednicer et al., The Organic Chemistry of Drug Synthesis, pp. 120 to 123, John Wiley & Sons, NY, (1977).
Poe Martin
Ruyle William V.
Merck & Co. , Inc.
Monaco Mario A.
Nicholson William H.
Randolph John D.
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