Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-09-08
1999-01-26
Wax, Robert A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530350, 530413, A61K 3816, C07K 1446, C07K 116
Patent
active
058638954
ABSTRACT:
A composition is provided that inhibits DNA replication in activated cell-free extracts of Xenopus eggs, which is prepared by a process comprising subjecting homogenates of Xenopus ovaries to a series of chromatographic separations so as to isolate a purified fraction comprising a protein having a molecular weight of about 245 kDa.
REFERENCES:
R.M. Benbow et al., "DNA Unwinding and Strand Synthesis During Replication in Xenopus laevis Embryos" in Advances in Applied Biotechnology Series, vol. 7, Gene Regulation and Aids, 69-86 (1990).
R.M. Benbow et al., "Cytoplasmic Control of Nuclear DNA Synthesis During Early Development of Xenopus laevis: A Cell-Free Assay", Proc. Natl. Acad. Sci. USA, 72, 2437-2441 (Jun. 1975).
J.J. Blow et al., "Initiation of DNA Replication in Nuclei and Purified DNA by a Cell-Free Extract of Xenopus Eggs", Cell, 577-587 (Nov. 21, 1986).
J.J. Blow et al., "A role for the nuclear envelope in controlling DNA replication within the cell cycle", Nature, 332, 546-548 (Apr. 7, 1988).
J.J. Blow et al., "Replication of purified DNA in Xenopus egg extract is dependent on nuclear assembly", J. Cell Sci., 95, 383-391 (1990).
J.J. Blow, "Preventing Re-replication of DNA in a Single Cell Cycle: Evidence for a Replication Licensing Factor", J. Cell Biol., 122, 993-1002 (Sep. 1993).
M.M. Bradford, "A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding", Anal. Biochem., 72, 248-254 (1976).
C.A. Casiano et al., "Autoantibodies to a novel cell cycle-regulated protein that accumulates in the nuclear matrix during S phase and is localized in the kinetochores and spindle midzone during mitosis", J. Cell Science, 106, 1045-1056 (1993).
R. Cortese et al., "Transition of tRNA genes in vivo: Single-stranded compared to double-stranded templates", Proc. Natl. Acad. Sci. USA, 77, 4147-4151 (Jul. 1980).
D. Coverley et al., "Regulation of Eukaryotic DNA Replication", Annu. Rev. Biochem., 63, 745-776 (1994).
L.S. Cox et al., "Extracts from eggs and oocytes of Xenopus laevis differ in their capacities for nuclear assembly and DNA replication", J. Cell Sci., 97, 177-184 (1990).
L.S. Cox, "DNA replication in cell-free extracts from Xenopus eggs is prevented by disrupting nuclear envelope function", J. Cell Sci., 101, 43-53 (1992).
J.N. Dumont, "Oogenesis in Xenopus laevis (Daudin)", J. Morph., 136, 153-179 (1972).
C.C. Ford et al., "DNA Synthesis in Oocytes and Eggs of Xenopus laevis Injected with DNA", Developmental Biology, 43, 189-199 (1975).
C.C. Ford et al., "A method for enucleating Oocytes of Xenopus laevis", J. Embryol. exp. Morph., 37, 203-209 (1977).
A.M. Fox et al., "Intracellular Localization of DNA Polymerase Activities within Large Oocytes of the Frog, Xenopus laevis", Developmental Biology, 80, 79-95 (1980).
C.F. Graham et al., "Induction of DNA Synthesis by Frog Egg Cytoplasm", Devlopmental Biology, 14, 349-381 (1966).
J.B. Gurdon, "On the Origin and Persistence of a Cytoplasmic State Inducing Nuclear DNA Synthesis in Frogs' Eggs", Proc. Natl. Sci. USA, 58, 545-552 (Aug. 1967).
J.B. Gurdon et al., "Changes in somatic cell nuclei inserted into growing and maturing amphibian oocytes", J. Embryol. exp. Morph., 20, 401-414 (Nov. 1968).
J.B. Gurdon et al., "The Appearance of Cytoplasmic DNA Polymerase Activity During the Maturation of Amphibian Oocytes into Eggs", Exp. Cell.. Res., 55, 253-256 (1969).
O. Haccard et al., "Induction of Metaphase Arrest in Cleaving Xenopus Embryos by MAP Kinase", Science, 262, 1262-1265 (Nov. 19, 1993).
R.M. Harland et al., "Regulated Replication of DNA Microinjected into Eggs of Xenopus Laevis", Cell, 21, 761-771 (Oct. 1980).
S. Hiraga et al., "In vitro replication of recombinant plasmids carrying chromosomal segments of Xenopus laevis", Proc. Natl. Acad. Sci. USA, 79, 3697-3701 (Jun. 1982).
C.J. Hutchison et al., "Periodic DNA synthesis in cell-free extracts of Xenopus eggs", EMBO J., 6, 2003-2010 (1987).
C.J. Hutchison et al., "The control of DNA replication in a cell-free extract that recapitulates a basic cell cycle in vitro", Development, 103, 553-566 (1988).
H.B. Kaiserman et al., "Characterization of a stable, major DNA polymerase or species devoid of DNA primase activity", Nucl. Acids Res., 15, 10249-10265 (1987).
U.K. Laemmli, "Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4", Nature, 227, 680-685 (Aug. 15, 1970).
M.J. Lohka et al., "Induction of Nuclear Envelope Breakdown, Chromosome Condensation, and Spindle Formation in Cell-Free Extracts", J. Cell Biol., 101, 518-523 (Aug. 1985).
J. Maller et al., "Changes in Protein Phosphorylation Accompanying Maturation of Xenopus laevis Oocytes", Developmental Biology, 58, 295-312 (1977).
J.L. Maller et al., "Progesterone-stimulated Meiotic Cell Division in Xenopus Oocytes", J. Biol. Chem.252, 1712-1718 (Mar. 10, 1977).
J. Marx, "How Cells Cycle Toward Cancer", Science, 263, 319-321 (Jan. 21, 1994).
J. Messing, "New M13 Vectors for Cloning", Methods Enzymol., 101, 20-79 (1983).
A.W. Murray, "Cell Cycle Extracts", Methods in Cell Biol., 36, 581-605 (1991).
J. Newport, "Nuclear Reconstitution In Vitro: Stages of Assembly around Protein-Free DNA", Cell, 48, 205 (Jan. 30, 1987).
I. Ruberti et al., "Large Scale Isolation of Nuclei from Oocytes of Xenopus laevis", Anal. Biochem., 180, 177-180 (1989).
J. Sambrook et al. in Molecular Cloning (A Laboratory Manual), Cold Spring Harbor Laboratory Press: Cold Spring Harbor, NY (1989). (Title Page, Copyright Page, and Contents Pages (pp. v-xxxii)).
M.A. Sheehan et al., "Steps in the Assembly of Replication-competent Nuclei in a Cell-free System from Xenopus Eggs", J. Cell Biol., 106, 1-12 (Jan. 1988).
C. Smith et al., "Preliminary Characterisation of Inhibitors of DNA Polymerase Isolated from Xenopus laevis Early Embryos", Biochim. Biophys. Acta, 741, 109-115 (1983).
L.D. Smith in The Biochemistry of Animal Development, vol. III; R. Weber, Ed.; Academic Press: New York; pp. 1-46 (1975).
J. Travis, "Looking for Cancer in Nuclear Matrix Proteins", Science, 259, 1258 (Feb. 26, 1993).
L-H. Tsai et al., "The cdk2 kinase is required for the G1-to-S transition in mammalian cells", Oncogene, 8, 1593-1602 (1993).
S. van den Heuvel et al., "Distinct Roles for Cyclin-Dependent Kinases in Cell Cycle Control", Science, 262, 2050-2054 (Dec. 24,1993).
A.H. Wyllie et al., "Selective DNA Conservation and Chromatin Assembly after Injection of SV40 DNA into Xenopus Oocytes", Development Biology, 64, 178-188 (1978).
J. Zhao et al., "An Inhibitor of DNA Topoisomerase I from Xenopus laevis Ovaries", Biochemistry, 32, 10622-10628 (1993).
J. Zhao et al., "Negative Control of Chromosomal DNA Replication in Cell-free Extracts of Xenopus laevis Eggs by Factors from Xenopus laevis Ovaries", Abstract of Papers, Eukaryotic DNA Replication Meeting, Sep. 8-12, 1993; Cold Spring Harbor Laboratory: Cold Spring Harbor, NY (1993).
J. Zhao et al., "Inhibition of DNA Replication in Cell-Free Extracts of Xenopus laevis Eggs by Factors from Xenopus laevis Ovaries", Abstract of Papers, 33rd Annual Meeting of the American Society for Cell Biology, New Orleans, LA (Dec. 11-15, 1993); printed in Supplement to Molecular Biology of the Cell, 4, 17a, Abstract No. 91 (Oct. 1993).
J. Zhao et al., "Inhibition of DNA Replication in Cell-Free Extracts of Xenopus laevis Eggs by Extracts of Xenopus laevis Oocytes", Developmental Biology, 164, 52-62 (1994).
Benbow Robert M.
Zhao Jiyong
Iowa State University Research Foundationv
Lau Kawai
Wax Robert A.
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