Inhibitor of atherosclerotic intimal thickening

Details Inhibitor of atherosclerotic intimal thickening Inhibitor of atherosclerotic intimal thickening

1992-09-30

2000-12-19

Henley, III, Raymond

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Silicon containing doai

514290, 514301, 514303, 514824, A61K 31695, A61K 3144

Patent

active

061627984

ABSTRACT:
An inhibitor of atherosclerotic intimal thickening, which contains an effective amount of a compound of the formula (I): ##STR1## wherein ring X is phenyl, substituted phenyl or 5- or 6-membered heterocyclic aryl and the remaining variables are as defined herein.

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The Merck Manual of Diagnosis and Therapy, Merck Research Laboratories, 1992, "Generalized Cardiovascular Disorders", pp. 410-411.
D.R. Sliskovic et al, "Inhibitors of Cholesterol Biosynthesis. 4. Trans-6-[2-(Substituted-Quinolinyl)-Ethenyl/Ethyl]Tetrahydro-4-Hydroxy-2H- Pyran-2-Ones, a Novel Series of HMG-CoA Reductase Inhibitors," J. Med. Chem., vol. 34 (1991), pp. 367-373.
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Journal of Medicinal Chemistry, vol. 34, No. 1, Jan. 1991, pp. 367-373, D.R. Sliskovic, et al., "Inhibitors of Cholestrol Biosynthesis.4."
Journal of American College of Cardiology, vol. 17, No. 1, Jan. 1991, pp. 251-259, J. Gellman, et al., "Effect of Lovastatin on Intimal Hyperplasia After Balloon Angioplasty: A Study in an Atherosclerotic Hypercholesterolemic Rabbit".
STN File Supplier, AN 91216498, vol. 82, No. 2, Feb. 1991, K. Oogushi, "Preventive Effect of Simvastatin, a Competitive Inhibitor of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase, on Coronary Atherosclerosis in Cholesterol-Fed Rabbits".
Pharmacology & Toxicology, vol. 64, No. 2, 1989, pp. 173-176, P. Falke, et al, "Effects of a Competitive Inhibitor (Mevinolin) of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase on Human and Bovine Endothelial Cells, Fibroblasts and Smooth Muscle Cells in Vitro".
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