Inhibitor compounds of zinc-dependent metalloproteinases associa

Details Inhibitor compounds of zinc-dependent metalloproteinases associa Inhibitor compounds of zinc-dependent metalloproteinases associa

1998-03-18

2000-05-02

Woodward, Michael P.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

548427, 548496, 562445, 562562, 562575, C07K 506

Patent

active

060572973

ABSTRACT:
Peptidomimetic compounds capable of inhibiting zinc-dependent metalloproteinases to treat pathological conditions associated with activation of endogenous metalloproteinases in mammals.

REFERENCES:
patent: 5472851 (1995-12-01), Pussard nee Contant
patent: 5504071 (1996-04-01), Politi
Bjarnason et al, "Hemorraghic Metalloproteinases from Snake Venoms", Pharmac. Ther., 21(3):325-372 (1994).
Calcagni et al, "Inhibitors of Zn-Dependent Metallopeptidases: Synthesis and Activity of N-(2-Furoyl)-(Z)-Alpha, Beta-Didehydroleucyl-L-Tryptophan", Farmaco, 48(9):1271-1277 (1991) (in Biobusiness, AN,93:82475).
Cushman et al, "Inhibitors of Angiotensin-Converting Enzyme" in The Renin-Angiotensin System, Johnson et al, Ed., Plenum Publishing Corp., New York (1980), pp. 199-225.
Giroux et al, "In Vivo Dimunition by Chelators of Snake Venom-Provoked Hemorrage and in Vitro Inhibition of Proteolytic Activity", Toxicon., 19(4):481-492 (1981).
Hite et al, "A New Family of Porteinases is Defined by Several Snake Venom Metalloproteinases", Biol. Chem. Hoppe-Seyler, 373:381-385 (1992).
Jiang et al, "Families of Metalloendopeptidases and Their Relationships", FEBS, 312(2.3):110-114 (1992).
Meier et al, "Effects of Snake Venoms on Hemostasis", Critical Reviews in Toxicology, 21(3):171-182 (1992).
Ondetti et al, "The Design of Active-Site Directed Reversible Inhibitors of Exopeptidases" in Drug Action and Design: Mechanism-Based Enzyme Inhibitors, Kalman, Ed., Elsevier North Holland Inc. (1979) pp. 229-225.
Robeva et al, "Synthetic and Endogenous Inhibitors of Snake Venom Metalloproteinases", Biomed. Biochim. Acta, 50(4-5):769-773 (1991).

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