Inhibiton of thromboxane synthetase with 1-substituted imidazole

Details Inhibiton of thromboxane synthetase with 1-substituted imidazole Inhibiton of thromboxane synthetase with 1-substituted imidazole

1979-02-21

1982-03-16

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

548341, A61K 31415, C07D23360

Patent

active

043201342

ABSTRACT:
The imidazole compounds of the general formula (I): ##STR1## wherein Y is a carboxyl group, a hydroxymethyl group, an N-di or -mono alkyl substituted or unsubstituted carbamoyl group, a cyano group, or an N-di or -mono alkyl substituted or unsubstituted aminomethyl group, and n is an integer of 3 to 20; and pharmaceutically acceptable salts thereof. These compounds have a strong inhibitory effect on thromboxane synthetase from rabbit platelet microsomes, and are useful as therapeutically active agents for inflammation, hypertension, thrombus, cerebral apoplexy and asthma.

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