Inhibition of wound contraction with paclitaxel, colchicine and

Details Inhibition of wound contraction with paclitaxel, colchicine and Inhibition of wound contraction with paclitaxel, colchicine and

1998-08-03

1999-06-29

Henley, III, Raymond

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514562, 514629, A61K 31335, A61K 31195, A61K 3116

Patent

active

059169133

ABSTRACT:
The present invention uses Paclitaxel and/or Colchicine in an appropriate carrier to inhibit wound contraction. Paclitaxel is an antimicrotubule agent that is currently used as a cancer chemotherapeutic drug. Colchicine inhibits microtubule dependent processes such as cell contraction and motility. It has been given orally for decades to treat gout. Previous studies using Colchicine to control wound contraction have been unsuccessful because of both local and systemic toxicity. Studies using the present invention demonstrate that Paclitaxel and Colchicine, when applied to wounds locally (either topically or by injection) in concentrations which are much lower than those previously studied, inhibit wound contraction, collagen deposition and granulation tissue growth. When combined with D-penicillamine, a drug that inhibits collagen cross-linking, the combination inhibits wound contraction, granulation tissue growth (nascent tissue that forms in the wound immediately post-injury), and intramuscular collagen deposition; epithelialization (sealing of the wound) is promoted.

REFERENCES:
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Joseph et al., Inhibition of Wound Contraction with Colchicine and D-Penicillamine, Journal of Surgical Research, vol. 61, No. 1, pp. 197-200, 1996.
Rennard, et al., Colchicine Suppress the Release of Fibroblast Growth Factors from Alveolar Macrophages in Vitro, Am. Rev. Respir. Dis., vol. 137, pp. 181-185, 1988.
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