Inhibition of viral replication

Details Inhibition of viral replication Inhibition of viral replication

1997-09-03

2000-05-09

Wortman, Donna C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C07H 2104

Patent

active

060605952

ABSTRACT:
The invention relates to methods and compositions for inhibition of viral replication in animal cells. In particular, inhibition of viral replication in a target cell is achieved by introducing into the cell (1) a protein which can be incorporated along with wild type nucleocapsid subunits into a viral nucleocapsid assembling within the cell, and thereby renders the nucleocapsid deficient in encapsidating viral nucleic acid; or (2) a recombinant nucleic acid construct that directs overexpression of the protein.

REFERENCES:
Birnbaum et al., "Hepatitis B Virus Nucleocapsid Assembly: Primary Structure Requirements in the Core Protein", Journal of Virology 64:3319-3330, 1990.
Hatton et al., "RNA-and DNA-Binding Activities in Hepatitis B Virus Capsid Protein: A Model for Their Roles in Viral Replication", Jounral of Virology 66:5232-5241, 1992.
Nassal, Michael, "The Arginine-Rich Domain of the Hepatitis B Virus Core Protein Is Required for Pregenome Encapsidation . . . ", Journal of Virology 66:4107-4116, 1992.
Scaglioni et al., "Characterization of Hepatitis B Virus Core Mutants That Inhibit Viral Replication", Virology 205:112-120, 1994.
Zhou et al., "Characterization of Hepatitis B Virus Capsid Particle Assembly in Xenopus Oocytes", Journal of Virology 66:3086-3092, 1992.

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