Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-02-05
2000-03-14
Dees, Jose' G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514277, 514284, 514290, 514301, 514510, 514557, A01N 4342, A01N 3700, A61K 3144, A61K 3121
Patent
active
060373482
ABSTRACT:
The present invention provides a method of inhibiting influenza and flaviviral replication based on a mechanism of action in which HA-mediated fusion or E protein mediated fusion is inhibited by a fusion inhibiting agent which binds, complexes or otherwise becomes associated with HA or E protein during the translation of the target protein and/or its vesicular transport.
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Bodian et al., "inhibition of the fusion-inducing conformational changes of influenza hemagglutinin by benzoquinones and hydroquinones", Biochemistry, 32, 2967-2978, 1993.
White et al., "Fusion mechanism of the influenza hemagglutinin: Inhibitor design" (Abstract), J. Cell Biochem., Suppl 16C, 111, 1992.
Colacino Joseph Matthew
Hatch Steven Duane
Hornback William Joseph
Muesing Mark Ayer
Munroe John Edwin
Dees Jos,e G.
Eli Lilly and Company
Lamm Marina
McClain Janet T.
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