Inhibition of viral protease activity by peptide halomethyl keto

Details Inhibition of viral protease activity by peptide halomethyl keto Inhibition of viral protease activity by peptide halomethyl keto

1984-08-29

1987-01-13

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 19, 530330, 530331, 2609982, A61K 3702, C07K 506, C07K 508, C07K 510

Patent

active

046364927

ABSTRACT:
Selected tripeptide and tetrapeptide halomethyl ketones are employed in processes for treating viral infection in mammals. These compounds inhibit picornavirus protease activity.

REFERENCES:
Lozitskii, et al., Usp. Sovrem. Biol. 93:352, (1982).
Korant, J. Virol. 10:751, (1972).
Summers et al., J. Virol. 10:880, (1972).
Korant et al., PNAS USA 76:2992, (1979).
Powers, "Halomethyl Ketone Inhibitors of Proteolytic Enzymes," in Weinstein, ed., Chemistry and Biochemistry of Amino Acids, Peptides, and Proteins, (Dekker, New York, 1977), pp. 65-178.
Powers et al., Biochim. Biophys. Acta 480:246, (1977).
Ito et al., Biochem. Biophys. Res. Comm. 49:343, (1972).
Fittkau et al., Peptides, 1982, p. 617, (1983).
Enzyme Systems Products (Product Bulletin, Nov. 1981).

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