Inhibition of viral infection

Details Inhibition of viral infection Inhibition of viral infection

1994-09-08

1997-05-27

Nazario-Gonzalez, Porfirio

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514309, 514616, 514619, A61K 31165, A61K 3147

Patent

active

056332823

ABSTRACT:
The use of a poly(ADP-ribose) polymerase inhibitor for the treatment of a subject against infection by a virus, in which the viral or proviral DNA integrates into the chromosome or chromosomes during its replication cycle.

REFERENCES:
patent: 5482975 (1996-01-01), Kun et al.
D ery et al. Virus Research (1986), 313-329 Possible role of ADP-ribosylation of adenovirus core proteins in virus infection.
Child et al. Virus Research (1988), 9 119-132 Inhibition of vaccinia virus replication by nicotinamide: evidence for ADP-ribosylation of viral proteins.
Farzaneh et al. Nucleic Acid Research (1988), 16 11319-11326 ADP-ribosylation is involved in the integration of foreign DNA into the mammalian cell genome.
Pandey et al. J. Ind. Chem. Soc. (1979), LVI 706-707 Search for new antiviral agents Part I. Synthesis of 2-phenyl-3-(alkyl-benzimidazolyl)quinazolin-4-ones.
Tseng et al. Proc. Natl. Acad. Sci. USA (1987), 84 1107-1111 Prevention of tumorigenesis of oncogene-transformed rat fibroblasts with DNA site inhibitors of poly(ADP-ribose) polymerase.

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