Inhibition of viral gene activities

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...

Reexamination Certificate

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C435S005000, C435S006120, C435S007100, C435S007800, C436S501000, C536S023720

Reexamination Certificate

active

06960429

ABSTRACT:
A method of inhibiting viral gene activities (and cellular gene activities) is disclosed. In one embodiment, the method comprises the step of delivering an effective amount of an inhibitor of a viral looping/linking factor to an infected patient.

REFERENCES:
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J. Cote et al., “Perturbation of Nucleosome Core Structure by the SWI/SNF Complex Persists After its Detachment, Enhancing Subsequent Transcription Factor Binding,” Proc. Natl. Acad., 95:4947-4952, 1998.
G. Orphanides, et al., “FACT, a Factor that Facilitates Transcript Elongation Through Nucleosomes,” Cell 92:105-116,1998.
D. Mackey and B. Sugden, “The Linking Regions of EBNA1 are Essential for Its Support of Replication and Transcription,” Mol. Cell. Biol. 19(5):3349-3359, 1999.

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