Drug – bio-affecting and body treating compositions – Identification or warning feature – Taste or smell or chemical irritation to the eye – nose – or...
Patent
1980-08-08
1984-01-17
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Identification or warning feature
Taste or smell or chemical irritation to the eye, nose, or...
424287, A61K 3128
Patent
active
044263724
ABSTRACT:
Dithiocarbamic compounds, administered about 0.5 to about 6 hours after Pt(II) compound, have been found to counter the toxicity of the platinum in multicellular organisms (e.g. mammals). For example, neoplastic growths in mammals can be treated with cis-diamine or cis-diammine Pt(II) complexes with greatly lessened risk of nephrotoxicity and damage to the digestive system of the mammal, provided the dithiocarbamic compound is timely (and preferably parenterally) administered. Particularly effective dithiocarbamic compounds are monomeric (e.g. ##STR1## where M.sup..sym. is a pharmaceutically acceptable cation and R.sup.1 and R.sup.2 are lower aliphatic or cycloaliphatic groups) or, less preferably, dimeric, e.g. ##STR2## wherein R.sup.1 and R.sup.2 are as defined previously, and R.sup.3 and R.sup.4 are defined in the same manner as R.sup.1 and R.sup.2. These dithiocarbamic compounds do not significantly reduce the desired effects of the Pt(II) compounds (particularly when the dithiocarbamic compound is intravenously administered), despite their effectiveness in reducing harmful side effects.
REFERENCES:
Borch et al., Proc. Natl. Acad. Sci. (USA), vol. 76, No. 12, pp. 6611-6614, (1979).
Chemical Abstracts 91: 117166d (1979).
Goldberg Jerome D.
Regents of the University of Minnesota
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