Inhibition of tumor growth by blockade of the protein C system

Details Inhibition of tumor growth by blockade of the protein C system Inhibition of tumor growth by blockade of the protein C system

1989-08-04

1992-09-15

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Lymphokine

424 851, 424 852, 424 854, 424 855, 435212, 514 2, 514 8, 514 12, 530351, 530381, 53038825, 5303893, A61K 3700, A61K 3766, A61K 3900

Patent

active

051476380

ABSTRACT:
Compositions, and methods of use thereof, for the inhibition of tumor growth and killing of tumors having extensive microcirculation wherein the active agent is a compound blocking the Protein C system, preferably anti-Protein C antibody, anti-Protein S antibody, and C4b binding protein. In the most preferred embodiment, the Protein C blocking compound is provided in combination with a cytokine such as tumor necrosis factor (TNF), gamma interferon, interleukin-1, interleukin-2 and granulocyte-macrophage colony stimulating factor. Examples are provided demonstrating the administration of the Protein C blocking compound, alone or in combination with TNF, to dogs having canine veneral tumors, or fibrosarcoma, and an adenocarcinoma, and pigs with melanoma followed by significant tumor reduction.

REFERENCES:
patent: 4650674 (1987-03-01), Aggarwal et al.
patent: 4677064 (1987-06-01), Mark et al.
patent: 4775624 (1988-10-01), Bang et al.
Cannistra et al. (1987) J. Clin. Invest 79, 1720-1728.
Suzuki et al. (1984) J. Biochem. 95, 187-195.
Nawroth et al. (1986) J. Exp. Med. 163, 740-745.
Dahlback (1986) J. Biol. Chem. 261, 12022-12027.
Suzuki et al., J. Biochem., 97(1), 127-138 (Jan. 1985).
Nussenzweig and Melton, Methods in Enzymology, 80, 124-133 (1981).
Laurell et al., FEBS Letters, 191(1), 75-81 (Oct. 1985).
Ohlin and Stenflo, J. Biol. Chem., 262(28), 13798-13804 (Oct. 5, 1987).
Dahlback, Biochem. J., 209, 837-846 (1983).
Liao et al., Cancer Immunol. Immunother. 28(1), 77-86 (1989).
Avner et al., J. Biol. Response Modifiers, 8(1), 25-36 (1989).

Affiliated with

Also associated with

Rating

Inhibition of tumor growth by blockade of the protein C system does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Inhibition of tumor growth by blockade of the protein C system, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibition of tumor growth by blockade of the protein C system will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-734951