Inhibition of tumor growth and metastasis with calcium channel b

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514211, 514255, 514523, 514654, A61K 3144, A61K 3155, A61K 31495, A61K 31275, A61K 31125

Patent

active

046909354

ABSTRACT:
The use of calcium channel blocker compounds as antitumor and antimetastatic agents in mammals in vivo and in standard laboratory experimets with tumor cells in vitro is described. In particular the use of nimodipine (Bay e 9736) or nifedipine (Bay a 1040) and structurally related compounds as described.

REFERENCES:
Chemical Abstracts 97:156177b, (1982).
Chemical Abstracts 99:205750k, (1983).
Weiss, L. In: Fundamental Aspects of Metastasis, pp. 1-5, 1976.
Fidler, I. J., Methods Cancer Res., 25:399-439, 1978.
Clark, R. L., Cancer 43:790-797, 1979.
Gordon, J. L. In: Platelets in Biology and Pathology-2. J. L. Gordon, ed., Elsevier North Holland Biomedical Press Amsterdam, pp. 1-7, 1981.
Weiss, H. J. In: Platelets: Pathophysiology and Antiplatelet Drug Therapy, Alan R. Liss, Inc., New York, pp. 13-17, 1982.
Jamieson, G. A., Bastida, E. and Ordinas, A. In: Interaction of Platelets and Tumor Cells, G. A. Jamieson, ed., Alan R. Liss Inc., New York, pp. 405-413.
Gasic, G. J., Gasic, T., Galanti, N., Johnson, T. and Murphy, S., int. J. Cancer 11:704-718, 1973.
Hara, H., Steiner, M. and Baldini, M. G., Cancer Res. 40:1217-1222, 1980.
Bastida, E., Ordinas, A. and Jamieson, G. A., Nature 291:661-662, 1981.
Gasic, G. J., Gasic T. B. and Steward, C. C., Proc. Natl. Acad. Sci. USA 61:46-52, 1968.
Honn, K. V., Cicone, B. And Skoff, A., Science 212:1270-1272, 1981.
Menter, D., Neagos, G., Dunn, J., Palazoo, R., Tchen, T. T., Taylor, J. D. and Honn, K. V. In: Prostaglandins and Cancer, First Intl. Conf., pp. 809-813, 1982.
Mustard, J. F. and Packham, M. A. Pharmac. Rev. 22:97-187, 1970.
Mills, D. C. and MacFarlane, D. E. In: Platelets in Biology and J. L. Gordon, ed., North Holland Press, New York, pp. 159-163, 1976.
Meyers, K. M., Seachord, C. L., Holmsen, H., Smith, J. B. and Prieur, D. J., Nature 282:313-333, 1979.
Shaw, J. O. and Lyons, R. M., Biochem. Biophys., Acta 714:492-499, 1982.
Imai, A., Kawai, K. and Nozawa, Y., Biochem. Biophys. Res. Commun., 108:(2) 752-759, 1982.
Kao, K. J., Sommer, J. R. and Pizzo, S. V., Nature 292:(5818) 82-84, 1981.
Gerrard, J. M., Peterson, D. A. and White, J. G. In: Platelets in Biology and Pathology-2, J. L. Gordon, ed., North Holland Biomedical Press, Amsterdam, pp. 407-436, 1981.
Rittenhouse-Simmons, S. L. Biol. Chem., 256:(9) 4153-4155, 1981.
Shukla, S. D., Life Sciences 30:1323-1335, 1982.
Serhan, C. N., Fridovish, J., Goetzel, E. J., Dunham, P. B. and Weissman, G. J., Biol. Chem. 257:(9) 4746-4752, 1982.
Gorman, R. R., Fed. Proc. 38:(1) 83-88, 1979.
Parise, L. V., Venton, D. L. and Ledreton, G. D., J. Pharm. Exptl. Therap. 222:(1) 276-281, 1982.
Circulation 62, (Suppli. III, Abstracts No. 1123,1258), abstract of 53rd Scientific Session 62, Suppli. III, Oct. 1980.
Fleckenstein A., An. Rev. Pharmacal. Toxical 17:149-166, (1977).
Exptl. Cell Res., 13:341-347, (1957).
Anal. Biochem. 98:112-115, (1979).
Diglio, C. A., Grammas, P., Giacomelli, F., and Wiener, J., Lab. Investigations, vol. 46, No. 6, pp. 554-563, 1982.
Diglio, C., Wolfe, D. E., and Meyers, P. J. Cell. Biol. Manuscript in press, 1983.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Inhibition of tumor growth and metastasis with calcium channel b does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Inhibition of tumor growth and metastasis with calcium channel b, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibition of tumor growth and metastasis with calcium channel b will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1265131

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.