Inhibition of trichothecene toxins by ancymidol

Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Fungi

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435929, 426321, 426331, 426419, 514258, C12N 114, C12R 177, A01N 4348, A23L 334

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048164062

ABSTRACT:
The compound ancymidol, a known potent plant growth retardant and weak fungicide, has now been found to inhibit biosynthesis of trichothecene toxins on substrates susceptible to growth of trichothecene-producing fungi. These fungi are known to contaminate cereal grains, forage crops, and potatoes. The effective level of ancymidol addition for toxin inbibition is substantially less than that required for control of fungal growth.

REFERENCES:
Coolbaugh et al., Plant Physiol. 62: 571-576 (1978).
P. Leroux et al., "Resistance to Fungicides which Inhibit Ergosterol Biosynthesis on Laboratory Strains of Botrytis Cinerea and Ustilago Maydis", Pestic. Sci. 15: 85-89 (1984).
J. B. Shive, Jr. et al., "Effects of Ancymidol (A Growth Retardant) and Triarimol (A Fungicide) on the Growth, Sterols, and Gibberellins of Phaseolus Vulgaris (L.)", Plant Physiol. 57: 640-644 (1976).
A. Ali et al., "Inhibition of Fungal Growth by Plant Growth Retardants", Notes, Can J. Bot. 57: 458-460 (1979).
R. C. Coolbaugh et al. "Comparative Effects of Substituted Pyrimidines on Growth and Gibberellin Biosynthesis in Gibberella Fujikuroi", Plant Physiol. 69: 712-716 (1982).

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