Inhibition of transforming growth factor beta activity

Details Inhibition of transforming growth factor beta activity Inhibition of transforming growth factor beta activity

1994-03-14

1996-12-10

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 530350, 530399, 530380, A61K 3819, C07K 14495

Patent

active

055831036

ABSTRACT:
The present invention provides a method of inhibiting an activity of TGF.beta. comprising contacting the TGF.beta. with a purified decorin. In a specific embodiment, the present invention relates to the ability of decorin, a 40,000 dalton protein that usually carries a glycosaminoglycan chain, to bind TGF.beta.. The invention also provides a novel cell regulatory factor designated MRF. Also provided are methods of identifying, detecting and purifying cell regulatory factors and proteins which bind and affect the activity of cell regulatory factors.

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