Inhibition of thromboxane synthetase with 3-(imidazol-1-ylalkyl)

Details Inhibition of thromboxane synthetase with 3-(imidazol-1-ylalkyl) Inhibition of thromboxane synthetase with 3-(imidazol-1-ylalkyl)

1979-02-22

1980-08-12

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

548336, A61K 31415, C07D40306

Patent

active

042173574

ABSTRACT:
A series of unsubstituted and substituted 3-(imidazol-1-ylalkyl)indole compounds has been prepared by reacting the appropriately substituted 3-methylindole starting material with imidazole per se, followed by further reaction with a proper acylating or alkylating agent of choice, if so desired. The resulting indole derivatives are useful in therapy for the treatment at ischaemic heart disease, migraine, transient ischaemic attack and stroke. Typical members include such preferred compounds as 3-(imidazol-1-ylmethyl)-1-methylindole and 3-(imidazol-1-ylmethyl)-2-isopropylindole, respectively.

REFERENCES:
patent: 3931229 (1976-01-01), Zinnes et al.
Andreani et al., J. Chem. Soc. (London) C, 1970, pp. 1157-1161.
Decodts et al., C. R. Acad. Sci., Paris, Ser. C, 1968, vol. 266, pp. 1168-1170.

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